1. Osteonecrosis after intranasal injection with bevacizumab in treating hereditary hemorrhagic telangiectasia: A case report.
- Author
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Steineger J, Merckoll E, Slåstad JM, Eriksen EF, Heimdal K, and Dheyauldeen S
- Subjects
- Administration, Intranasal adverse effects, Aged, Angiogenesis Inhibitors administration & dosage, Bevacizumab administration & dosage, Humans, Injections adverse effects, Knee, Male, Nasal Mucosa, Treatment Outcome, Angiogenesis Inhibitors adverse effects, Bevacizumab adverse effects, Osteonecrosis chemically induced, Telangiectasia, Hereditary Hemorrhagic drug therapy
- Abstract
Intranasal bevacizumab injections have been used in treating hereditary hemorrhagic telangiectasia (HHT)-related epistaxis since 2009. It is believed to be a safe and effective treatment for a selected group of HHT patients in reducing frequency and intensity of epistaxis, with few or none adverse effects. In this case report, however, we will describe a patient who developed bilateral osteonecrosis in the knees while undergoing regular intranasal submucosal bevacizumab injections. Although osteonecrosis previously has been documented in patients receiving bevacizumab intravenously in oncologic doses, thus far it has not been reported in patients treated with intranasal submucosal injections. Laryngoscope, 128:593-596, 2018., (© 2017 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2018
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