Background: Cervical laminoplasty is a well-established surgical treatment for patients with cervical myelopathy due to OPLL. However, for cases with OPLL involving C2 segment, some surgeon preferred C2EL technique, but destruction of muscles attaching at C2 spinous process and lamina is inevitable. While C2DEL technique was also available which cause less destruction to the structures associated with C2. Nevertheless, it is still not confirmed whether it can achieve similar outcomes as C2EL. This study aimed to compare the clinical and radiographic outcomes of C2 dome-like expansive laminoplasty technique(C2DEL) and C2 extended laminoplasty technique(C2EL) applied in the treatment of cervical ossification of posterior longitudinal ligament (OPLL)involving C2 segment.Methods: Data of 56 patients with OPLL involving C2 segment who underwent cervical laminoplasty were retrospectively reviewed. 26 patients received C2EL technique while C2DEL technique was applied in another 30 patients. Functional outcomes evaluated by visual analog scale score for neck pain (VASSNP), Neck Disability Index (NDI), Japanese Orthopedic Association (JOA) score and Health-Related Quality-of-Life Short Form-36 Physical Component Summary (SF-36 PCS) were recorded and compared pre- and postoperatively. The radiographic outcomes assessed by the Cobb angle and range of motion (ROM) of cervical spine at C2-C7, as well as decompression effect at C2 level evaluated by space available for spinal cord (SAC) were measured in two groups. The intraoperative parameters including total blood loss and operation time were documented and compared between 2 groups.Results: At the final follow-up, JOA scores, NDI, and SF-36 PCS were significantly improved in both groups(all P<0.05), but no significant differences were identified between two groups. VASSNP was reduced significantly in both groups(P<0.05), but the cases in C2EL group experienced more severe neck pain than that of C2EL group(P<0.05). Cobb angle at C2 and C7 and the cervical ROM in both groups reduced greatly, the SAC at C2 improved postoperatively and no significant difference was identified intergroup. No serious complications related to the surgical approach and instrumentation were observed in either group.Conclusion: C2DEL was comparable to C2EL for treating OPLL involving C2 segment. C2DEL was an ideal alternative treatment strategy for OPLL involving the C2 segment.