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During recent decades the utilisation of growth factors, especially BMPs, has received an increasing interest in orthopaedic surgery. For clinical implantation the two main options are demineralised bone matrix (DBM) and recombinant bone morphogenetic proteins (rhBMP). Many clinical studies agree on an equivalent osteoinductive effect between DBM, BMPs and autologous bone graft; however, the different origins and processing of DBM and rhBMP may introduce some fluctuations. Their respective characteristics are reviewed and possible interactions with their effectiveness are analysed. The main difference concerns the concentration of BMPs, which varies to an order of magnitude of 10 between DBM and rhBMPs. This may explain the variability in efficiency of some products and the adverse effects. Currently, considering osteoinductive properties, safety and availability, the DBM seems to offer several advantages. However, if DBM and rhBMPs are useful in some indications, their effectiveness and safety can be improved and more evidence-based studies are needed to better define the indications. [ABSTRACT FROM AUTHOR]

In this article, the author offers information related to an international non-profit association International Society of Orthopedic Surgery & Traumatology (SICOT) with the aim to advance the science and art of orthopedics and Traumatology. He further discusses the violent aggression against orthopedic surgeons and traumatologists and nurses working in emergency departments during war or due to drug abuse, ignorance and intolerance.

The article discusses the assistance provided by the International Society of Orthopaedic Surgery and Traumatology (SICOT) during natural disasters. After the 2005 earthquake in Pakistan, many SICOT members offered their services as orthopaedic surgeons and provide medical assistance to victims. A collaboration with Médecins Sans Frontières has been formed by SICOT in 2006. The assistance provided by SICOT during the 2010 earthquake in Haiti is also noted.

The article offers information on the XXV Triennial World Congress – SICOT 2011 that will be held in Prague, Czech Republic from September 6 to 9, 2011.