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Your search keyword '"Mokhtar Boualem Lahrech"' showing total 4 results
Start Over Author "Mokhtar Boualem Lahrech" Topic organometallic complex
4 results on '"Mokhtar Boualem Lahrech"'

1. Synthesis, characterization and biological activity of Hg(II), Fe(III) complexes with 1,3,4-oxadiazole, 1,2,4-triazole derivatives from L-methionine

Author

Khaled Briki, Adil Ali Othman, Mouna Souad Abbassi, and Mokhtar Boualem Lahrech

Subjects
L-Methionine, Diazole thiols, Ligands, Organometallic complex, Antibacterial activity, Chemistry, QD1-999
Abstract

Four novel heterocyclic1,3,4-oxadiazole, 1,2,4-triazole derivatives, namely: 5-[1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazole-2(3H)-thione (4), 4-amino-5-[1-amino-3-(methylsulfanyl)propyl]-4H-1,2,4-triazole-3-thiol (5), 1-amino-3-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-5-thiol (7), and 5-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-3-thiol (9) have been synthesized from l-methionine and characterized by different spectroscopic techniques (FT-IR, UV–Vis, 1H NMR, 13C NMR and MS). Complex formation with Hg++ and Fe+++ ions were formed from the four heterocyclic 4, 5, 7 and 9. The antimicrobial activities for synthetic intermediates and final four products were assisted using paper disk diffusion method against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923, Staphylococus aureus 43300 and showed variant activity against some of the microorganisms tested.

Published
2020
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2. Synthesis of diazole-thiols derivatives from l-cysteine: Characterization, complex formation with Ni(II), Cu(II) and evaluation of their antibacterial activity

Author

Mouna Souad Abbassi, Adil Ali Othman, Khaled Briki, and Mokhtar Boualem Lahrech

Subjects
l-Cysteine, Diazole thiols, Ligands, Organometallic complex, Antibacterial activity, Chemistry, QD1-999
Abstract

Four novel diazole-thiol derivatives namely: 5-(1-amino-2-sulfanylethyl)-1,3,4-oxadiazole-2(3H)-thione 6, 4-amino-5-(1-amino-2-sulfanylethyl)-4H-1,2,4-triazole-3-thiol 7, 1-amino-3-(1-amino-2-sulfanylethyl)-1H-1,2,4-triazole-5-thiol 8, and 5-(1-amino-2-sulfanylethyl)-1H-1,2,4-triazole-3-thiol 9 have been synthesized from l-Cysteine and characterized by IR, 1H NMR, 13C NMR and GC–MS. Complex formation with Ni(II) and Cu(II) ions with four diazole-thiol derivatives of l-Cysteine were formed and isolated. The final synthetic products (6–9) and their corresponding Ni(II) and Cu(II) complexes (6a,a′-9a,a′) were tested against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923 and showed no biological activity. While Ni(II) and Cu(II) complexes of 7–9 exhibited appreciable activity against tested microorganisms. The outstanding results is that the Cu(II)-complexes 8a′ and 9a′ showed their (MIC) activity on similar organisms at very low concentrations (5 µg/ml) which is in fact lower concentration than what had been reported on other relative compounds.

Published
2021
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3. Synthesis, characterization and biological activity of Hg(II), Fe(III) complexes with 1,3,4-oxadiazole, 1,2,4-triazole derivatives from L-methionine

Author

Adil Ali Othman, Khaled Briki, Mouna Souad Abbassi, and Mokhtar Boualem Lahrech

Subjects
biology, Pseudomonas, Oxadiazole, 1,2,4-Triazole, L-Methionine, Biological activity, General Chemistry, Organometallic complex, Carbon-13 NMR, biology.organism_classification, medicine.disease_cause, Ligands, Medicinal chemistry, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, Proton NMR, medicine, Diazole thiols, Agar diffusion test, Antibacterial activity, Escherichia coli
Abstract

Four novel heterocyclic1,3,4-oxadiazole, 1,2,4-triazole derivatives, namely: 5-[1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazole-2(3H)-thione (4), 4-amino-5-[1-amino-3-(methylsulfanyl)propyl]-4H-1,2,4-triazole-3-thiol (5), 1-amino-3-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-5-thiol (7), and 5-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-3-thiol (9) have been synthesized from l-methionine and characterized by different spectroscopic techniques (FT-IR, UV–Vis, 1H NMR, 13C NMR and MS). Complex formation with Hg++ and Fe+++ ions were formed from the four heterocyclic 4, 5, 7 and 9. The antimicrobial activities for synthetic intermediates and final four products were assisted using paper disk diffusion method against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923, Staphylococus aureus 43300 and showed variant activity against some of the microorganisms tested.

Published
2020

4. Synthesis of diazole-thiols derivatives from -cysteine: Characterization, complex formation with Ni(II), Cu(II) and evaluation of their antibacterial activity

Author

Adil Ali Othman, Mouna Souad Abbassi, Khaled Briki, and Mokhtar Boualem Lahrech

Subjects
Organometallic complex, Ligands, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, l-Cysteine, medicine, QD1-999, Escherichia coli, biology, 010405 organic chemistry, Pseudomonas, Biological activity, General Chemistry, Carbon-13 NMR, biology.organism_classification, 0104 chemical sciences, Chemistry, chemistry, Proton NMR, Diazole thiols, Diazole, Antibacterial activity, Nuclear chemistry, Cysteine
Abstract

Four novel diazole-thiol derivatives namely: 5-(1-amino-2-sulfanylethyl)-1,3,4-oxadiazole-2(3H)-thione 6, 4-amino-5-(1-amino-2-sulfanylethyl)-4H-1,2,4-triazole-3-thiol 7, 1-amino-3-(1-amino-2-sulfanylethyl)-1H-1,2,4-triazole-5-thiol 8, and 5-(1-amino-2-sulfanylethyl)-1H-1,2,4-triazole-3-thiol 9 have been synthesized from l-Cysteine and characterized by IR, 1H NMR, 13C NMR and GC–MS. Complex formation with Ni(II) and Cu(II) ions with four diazole-thiol derivatives of l-Cysteine were formed and isolated. The final synthetic products (6–9) and their corresponding Ni(II) and Cu(II) complexes (6a,a′-9a,a′) were tested against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923 and showed no biological activity. While Ni(II) and Cu(II) complexes of 7–9 exhibited appreciable activity against tested microorganisms. The outstanding results is that the Cu(II)-complexes 8a′ and 9a′ showed their (MIC) activity on similar organisms at very low concentrations (5 µg/ml) which is in fact lower concentration than what had been reported on other relative compounds.

Published
2021

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