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Abstract: (5R,6S,E)-5-Alkyl-2-(2-(methoxymethoxy)ethylidene)-6-(phenylsulfonyl)cyclohex-3-enones, have been obtained by a domino reaction using tandem catalysis with a Nazarov reagent 3, and several unsaturated aldehydes. [Copyright &y& Elsevier]

Abstract: Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate. [Copyright &y& Elsevier]

Abstract: This paper describes the use of zamoranic acid in the first semisynthesis of the furolabdane (+)-angeloyl-gutierrezianolic acid methyl ester diterpenoid, which also establishes the absolute configuration of the natural product. Direct deconjugation of Δ7 in zamoranic acid and Bestmann methodology for the furan ring synthesis are the key steps. [ABSTRACT FROM AUTHOR]

Abstract: ent-Halimic acid has been used in the synthesis of the quinone/hydroquinone sesquiterpenes (−)-aureol, (−)-smenoqualone, (−)-neomamanuthaquinone and in the formal synthesis of (−)-cyclosmenospongine. [ABSTRACT FROM AUTHOR]

Abstract: This paper describes the use of (−)-sclareol in the synthesis of the tricyclic diterpenes of abietane skeleton, such as (+)-ferruginol and (+)-sugiol, using as key step the lateral lithiation of a dinorditerpene derivative. [Copyright &y& Elsevier]

Abstract: Description of the first synthesis of (+)-makassaric acid, an important kinase MK2 inhibitor. The key step was a Barton/McCombie radical deoxygenation. [Copyright &y& Elsevier]

Abstract: Herein, the synthesis of 4-methyldecarboxyhaumanamide (9) and 4-methyldecarboxyspongolactams A (11) and C (13) is presented. (−)-Sclareol is the starting material and the chloroderivative 7 is the common intermediate. Moreover, this synthesis represents a new strategy for the preparation of pyrrolinones. [Copyright &y& Elsevier]

Abstract: This paper describes the use of (−)-sclareol in the first synthesis of the spirolabdanolide (+)-leopersin D, which also establishes the absolute configuration of the product. The reversibility of conjugate addition/elimination of oxaspirolabdanolide formation is demonstrated. [Copyright &y& Elsevier]

Abstract: Several 6,7-dioxygenated (cis or trans) labdanes have been synthesised starting from sclareol. A new strategy that allows the obtention of diols α-cis as well as β-cis or trans is described. In particular, the syntheses of three natural highly functionalised labdanes in the B rings of 2, 3 and 4 with different side chains are reported. The syntheses have permitted to correct the proposed structure for one of them. [Copyright &y& Elsevier]