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The reaction of 1,2-diaminoethane with vinylphosphonate occurs as the addition of the amino group to the β -carbon atom of the unsaturated substrate to give 1:1 and 1:2 adducts. The nucleophilic addition of 2-aminoethanol at the β -position of the double bond of vinylphosphonates involves only the amino group and leads to the formation of hydroxy β -aminoethylphosphonates or zwitterions depending on conditions.

Dialkyl 3-methylbuta-1,2-dienyl- and vinylphosphonates take up imidazole at the β-carbon atom in the unsaturated fragment to give the corresponding β-(1H-imidazol-1-yl)alkenyl-and alkylphosphonates.

Mixing an excess of 3-methyl-1,2-butadienylphosphonate with 1,2-diaminoethane, 1,2-diaminopropane, or 4,7,10-trioxa-1,13-tridecandiamine leads to the formation of bis-(aminoalkenylphosphonates).