1. A community-based RCT for oral cancer screening with toluidine blue.
- Author
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Su WW, Yen AM, Chiu SY, and Chen TH
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Areca, Chi-Square Distribution, Confidence Intervals, Early Detection of Cancer, Humans, Male, Middle Aged, Smoking, Young Adult, Coloring Agents, Leukoplakia, Oral diagnosis, Mass Screening methods, Mouth Neoplasms diagnosis, Oral Submucous Fibrosis diagnosis, Precancerous Conditions diagnosis, Tolonium Chloride
- Abstract
Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10(-5)) was non-significantly 21% lower than that in the control group (35.4 x 10(-5)).
- Published
- 2010
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