1. Deep photothermal effect induced by stereotactic laser beams in highly scattering media
- Author
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Mario Enrique Álvarez-Ramos, Armando Lucero-Acuña, L. Baez-Castillo, R. C. Carrillo-Torres, Neil C. Bruce, E. Ortiz-Rascón, and Jesús Garduño-Mejía
- Subjects
Plasmonic nanoparticles ,Optical fiber ,Materials science ,Scattering ,business.industry ,Phantoms, Imaging ,medicine.medical_treatment ,Lasers ,Photothermal effect ,Photothermal therapy ,Atomic and Molecular Physics, and Optics ,Radiosurgery ,Imaging phantom ,law.invention ,Optics ,law ,Neoplasms ,medicine ,Humans ,Nanoparticles ,Gold ,business ,Plasmon - Abstract
Plasmonic photothermal therapy (PPTT), as an increasingly studied treatment alternative, has been widely regarded mostly as a surface tissue treatment choice. Although some techniques have been implemented for interstitial tumors, these involve some grade of invasiveness, as the outer skin is usually broken to introduce light-delivering optical fibers or even catheters. In this work, we present a potential non-invasive strategy using the stereotactic approach, long employed in radiosurgery, by converging multiple near infrared laser beams for PPTT in tissue-equivalent optical phantoms that enclose small gel spheres and simulate interstitial tissue impregnated with plasmonic nanoparticles. The real-time in-depth monitoring of temperature increase is realized by an infrared camera face-on mounted over the phantom. Our results show that a significant reduction in the surface heating can be achieved with this configuration while remarkably increasing the interstitial reach of PPTT, assuring a ∼ 6 ∘ C temperature increase for the simulated tumors at 10 mm depth and ∼ 4 ∘ C at 15 mm depth and opening up new possibilities for future clinical applications.
- Published
- 2021