14 results on '"Lupidi, Marco"'
Search Results
2. Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos
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Abroug, Nesrine, Ksiaa, Imen, Lupidi, Marco, Nabi, Wejdene, Attia, Sonia, Jelliti, Bechir, Khochtali, Sana, and Khairallah, Moncef
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- 2019
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3. Deep inside Multifocal Choroiditis: an Optical Coherence Tomography Angiography approach
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Cerquaglia, Alessio, Lupidi, Marco, Fiore, Tito, Iaccheri, Barbara, Perri, Paolo, and Cagini, Carlo
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- 2017
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4. Predictive Factors of Visual Outcome in Treatment-Naïve Diabetic Macular Edema: Preliminary Results from the Clinical Study "FOVEA".
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Serra, Rita, Coscas, Florence, Boulet, Jean François, Cabral, Diogo, Tran, Thi Ha Chau, Solinas, Giuliana, Pinna, Antonio, Lupidi, Marco, and Coscas, Gabriel
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DIABETIC retinopathy ,MACULAR edema ,OPTICAL coherence tomography ,FLUORESCENCE angiography ,VISION disorders ,FRACTAL analysis - Abstract
Diabetic macular edema (DME) is a common cause of vision impairment in diabetic retinopathy. The aim of this study was to analyze the relationship between visual outcome and anatomic changes detected by traditional multimodal retinal imaging and optical coherence tomography angiography (OCTA) in DME eyes under treatment with Aflibercept. Methods: Sixty-six DME eyes of 62 patients under treatment with intravitreal Aflibercept and with one-year follow-up were enrolled. All participants underwent a full ophthalmic evaluation, including best correct visual acuity (BCVA) measurement, spectral-domain optical coherence tomography, fluorescein angiography and OCTA, both at baseline and final examination. Fractal OCTA analysis of the superficial and deep capillary plexus (SCP and DCP) was performed to estimate vascular perfusion density and lacunarity (LAC). Results: At the final examination, there was a significant improvement in terms of BCVA and central macular thickness (CMT). Furthermore, eyes with CMT <373 µm at baseline reached the higher BCVA at the last follow-up. Eyes with CMT ≥373 µm and DCP LAC <0.41 reached a higher final BCVA, if compared with eyes showing the same CMT but higher initial LAC. Conclusion: A 12-month treatment with intravitreal Aflibercept for DME resulted in significant visual and anatomic improvement. Multimodal retinal imaging, together with fractal OCTA analysis, may provide useful biomarkers, predictive of visual outcome in DME. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Real‐world outcomes of anti‐VEGF therapy in treatment‐naïve neovascular age‐related macular degeneration diagnosed on OCT angiography: the REVEAL study.
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Lupidi, Marco, Schiavon, Stefano, Cerquaglia, Alessio, Fruttini, Daniela, Gujar, Ramkailash, Muzi, Alessio, Fiore, Tito, Reibaldi, Michele, Chhablani, Jay, and Cagini, Carlo
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RETINAL degeneration , *POLYPOIDAL choroidal vasculopathy , *ANGIOGRAPHY , *OPTICAL coherence tomography , *FLUORESCENCE angiography , *VASCULAR endothelial growth factor antagonists - Abstract
Purpose: To compare the 12 months visual and anatomical outcomes of treatment‐naïve neovascular age‐related macular degeneration (nAMD) patients diagnosed by optical coherence tomography angiography (OCT‐A) compared with fluorescein angiography (FA)/indocyanine green angiography (ICGA), after anti‐VEGF treatment in a real‐world setting. Methods: Monocentric, observational, parallel‐group study of nAMD patients diagnosed with either FA/ICGA or non‐invasive OCT‐A methods. Patients were treated with a fixed dosing regimen of intravitreal ranibizumab or aflibercept and followed up for 12 months. Primary outcomes were the 12 months functional (BCVA) and anatomical (CST reduction) gains between the two groups. The stratification of BCVA and CST gains by type of neovascular lesion and by anti‐VEGF treatment was also assessed. Results: Seventy‐two patients received FA/ICGA for the initial diagnosis of nAMD, while 73 received OCT‐A. Overall, the mean BCVA gain at 12 months was 11.5 ± 9.6 letters. There were no statistically significant differences between the invasive and non‐invasive imaging groups in BCVA gain (p = 0.87) or CST reduction (p = 0.76). No statistically significant outcome differences between different lesion types and the two drugs were observed. Conclusion: In a real‐world setting, nAMD patients diagnosed with OCT‐A showed meaningful improvements in visual and anatomical parameters during 12 months of treatment, without significant differences with those diagnosed by invasive modalities. [ABSTRACT FROM AUTHOR]
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- 2022
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6. a predictive model for treatment decisions
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Coscas, Florence, Lupidi, Marco, Boulet, Jean François, Sellam, Alexandre, Cabral, Diogo, Serra, Rita, Français, Catherine, Souied, Eric H, Coscas, Gabriel, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)
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predictive model ,structuralOCT ,genetic structures ,exudative-AMD ,OCT angiography ,sense organs ,AMD, age-related macular degeneration ,choroidal neovascularisation ,optical coherence tomography angiography ,eye diseases - Abstract
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. AIMS: To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity. METHODS: Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. These findings were then correlated with those of structural OCT scans. A score forecast was built and validated. RESULTS: One hundred and twenty-six eAMD eyes were enrolled in the study. Exudation was observed in 90 eyes (71%) on structural OCT. The qualitative OCT-A analysis revealed: tiny branching vessels in 82.5% of the cases, vascular loops in 81.7%, peripheral anastomotic arcades in 66.7% and choriocapillaris hypointense halo in 54.8%. In the univariate analysis, each OCT-A parameter showed a statistically significant correlation with exudation on structural OCT (p
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- 2019
7. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RICKETTSIAL RETINITIS.
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Kahloun, Rim, Jelliti, Bechir, Ksiaa, Imen, Amor, Hager Ben, Zaouali, Sonia, Lupidi, Marco, Yahia, Salim Ben, and Khairallah, Moncef
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Purpose: To report optical coherence tomography angiography findings in a patient with rickettsial retinitis. Methods: A 29-year-old man complaining of acute blurring vision in the right eye associated with Rickettsia conorii infection underwent a comprehensive ocular examination, fluorescein angiography, spectral-domain optical coherence tomography, and sweptsource optical coherence tomography angiography. Results: Funduscopy showed two large areas of retinitis in the inferior macula along the distribution of the inferotemporal artery with associated retinal hemorrhages, retinal edema, and serous retinal detachment. Fluorescein angiography showed early hypofluorescence and late staining of white retinal lesions and associated adjacent retinal vascular leakage and optic disc hyperfluorescence. Optical coherence tomography angiography showed hypointense dark areas in the superficial capillary plexus and larger hypointense areas in the deep capillary plexus, outer retina, and choriocapillaris layer. The patient was treated with doxycycline and prednisone. Six weeks after presentation, retinal changes seen at the acute phase had resolved, leading to mild residual retinal pigment epithelial changes. Fluorescein angiography showed retinal capillary nonperfusion within areas of resolved retinitis. Spectraldomain optical coherence tomography findings included inner retinal atrophy, intraretinal cysts, and disruption of ellipsoid zone and interdigitation zone. Swept-source optical coherence tomography angiography showed well-delineated hypointense greyish areas of retinal capillary nonperfusion in both the superficial and deep capillary plexuses. Visual field testing revealed the presence of a corresponding paracentral defect. Conclusion: Optical coherence tomography angiography may be a valuable noninvasive imaging technique for detecting and analyzing occlusive complications associated with rickettsial retinitis. [ABSTRACT FROM AUTHOR]
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- 2019
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8. New Insights On Ocular Sarcoidosis: An Optical Coherence Tomography Angiography Study.
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Cerquaglia, Alessio, Iaccheri, Barbara, Fiore, Tito, Fruttini, Daniela, Belli, Federica Benedetta, Khairallah, Moncef, Lupidi, Marco, and Cagini, Carlo
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OPTICAL coherence tomography ,SARCOIDOSIS ,ANGIOGRAPHY ,FLUORESCENCE angiography ,SARCOIDOSIS diagnosis ,RETINA ,RESEARCH evaluation ,CROSS-sectional method ,RETROSPECTIVE studies ,UVEITIS ,VISUAL acuity ,LONGITUDINAL method - Abstract
Purpose: To report optical coherence tomography angiography (OCT-A) findings in eyes with ocular sarcoidosis (OS) and to compare these findings with those of fluorescein angiography (FA). Methods: Observational, cross-sectional, case-control study. Patients presenting with OS involving the posterior segment were evaluated using FA, structural-OCT and OCT-A. OCT-angiograms of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) were qualitatively and quantitatively analyzed. Results: OCT-A seemed more sensitive than FA in detecting perifoveal capillary arcade disruptions, areas of hypoperfusion/non-perfusion and capillary abnormalities (p<0.05). Capillary hypoperfusion was more frequently detected in the DCP than in SCP, conversely capillary abnormalities were more often observed at the level of the SCP. Capillary vessel density values were significantly lower in eyes with OS than in healthy controls both at the level of DCP and CC (p<0.05). Conclusion: The depth-resolved nature of OCT-A allowed new insights on OS-induced microvascular and perfusion impairments. [ABSTRACT FROM AUTHOR]
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- 2019
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9. Optical Coherence Tomography Angiography in Healthy Subjects and Diabetic Patients.
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Coscas, Gabriel, Lupidi, Marco, Coscas, Florence, Chhablani, Jay, and Cagini, Carlo
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OPTICAL coherence tomography , *RETINAL diseases , *DIABETIC retinopathy , *EYE examination , *RETINA - Abstract
Fluorescein angiography and indocyanine green angiography provide information about the normal retinal and choroidal vascular perfusion. They allow the evaluation of different diseases and increase the capability to define and diagnose several pathological conditions. Fluorescein angio graphy is the “gold standard” in imaging the retinal vascular bed and its changes, although not all the different layers of the capillary network can be visualized in a bidimensional examination. Optical coherence tomography angiography allows a depth-resolved visualization of the retinal and choroidal microvasculature, by calculating the difference (decorrelation) between static and nonstatic tissue. Given that the main moving elements in the eye fundus are contained in vessels, determining a vascular decorrelation signal permits a three-dimensional visualization of the retinal and choroidal vascular network without the administration of an intravenous dye. Moreover, a complete morphofunctional assessment may help in defining both the origin and the clinical activity of different vascular diseases such as diabetic retinopathy. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Retinal Microvasculature in Nonproliferative Diabetic Retinopathy: Automated Quantitative Optical Coherence Tomography Angiography Assessment.
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Lupidi, Marco, Coscas, Gabriel, Coscas, Florence, Fiore, Tito, Spaccini, Elisa, Fruttini, Daniela, and Cagini, Carlo
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RETINAL blood vessels , *DIABETIC retinopathy , *OPTICAL coherence tomography , *DISEASE progression , *EYE examination - Abstract
Purpose: To perform a qualitative and quantitative assessment of the foveal microvasculature in eyes with diabetic maculopathy using optical coherence tomography angiography (OCT-A). Methods: Retrospective case series of 48 eyes with diabetic maculopathy and 47 healthy eyes evaluated by Spectralis OCT-A. Perifoveal arcade disruptions, linear vascular dilations, microaneurysms, intraretinal microvascular abnormalities and flow-void areas were qualitatively analyzed on OCT angiograms both for the superficial (SCP) and deep (DCP) capillary plexuses. A fully automated microstructural analysis of the foveal avascular zone (FAZ) metrics, vascular and avascular surfaces was performed. Quantitative values from diabetic patients were compared with those of healthy subjects. Results: A moderate agreement between SCP and DCP in terms of diabetes-induced vascular lesions in the qualitative assessment was shown. The comparative quantitative analysis between SCP and DCP in diabetic patients revealed a statistically significant difference (p < 0.05) in terms of FAZ perimeter and FAZ surface. No statistically significant difference was shown in total vascular and avascular surfaces. A statistically significant difference between the diabetic and control groups was noticed both for SCP and DCP considering FAZ metrics and vascular surfaces. Conclusions: A qualitative and quantitative OCT-A approach on retinal vascular perfusion may offer an objective and reliable method for monitoring disease progression in diabetic retinopathy. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Optical Coherence Tomography Angiography during Follow-Up: Qualitative and Quantitative Analysis of Mixed Type I and II Choroidal Neovascularization after Vascular Endothelial Growth Factor Trap Therapy.
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Coscas, Gabriel, Lupidi, Marco, Coscas, Florence, Français, Catherine, Cagini, Carlo, and Souied, Eric H.
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OPTICAL coherence tomography , *ANGIOGRAPHY , *CHOROID diseases , *NEOVASCULARIZATION , *VASCULAR endothelial growth factors ,AGE factors in retinal degeneration - Abstract
Purpose: To report the optical coherence tomography angiography (OCT-A) findings in an exudative age-related macular degeneration (AMD) patient presenting mixed type I and II choroidal neovascularization (CNV) during follow-up after intravitreal vascular endothelial growth factor (VEGF) trap treatment. Methods: The clinical assessment included both traditional multimodal imaging, based on fluorescein angiography (FA), indocyanine green angiography (ICGA) and B-scan OCT, and OCT-A at baseline and follow-up. OCT-A images were obtained using a Spectralis OCT-A prototype able to acquire 70,000 A-scans per second, with a resolution of 7 µm axially and 14 µm laterally. An amplitude decorrelation algorithm developed by Heidelberg Engineering was applied to a volume scan, on a 15 × 5° area, which was composed of 131 B-scans (35 frames per scan) at a distance of 11 µm each. The borders of type I and type II CNV were manually outlined and then the areas were analyzed using the provided automated software before and after treatment. Results: The qualitative approach revealed a substantial decrease in the visibility of tiny branching vessels and anastomoses both in type I and type II components of the neovascular complex, associated with persistence of a clear hyperintense signal coming from the larger trunks, which remained well-perfused. Quantitative analysis confirmed a reduction of the lesion area after VEGF trap treatment: the type II component decreased from 0.25 to 0.19 mm2, while the type I component decreased from 2.03 to 1.80 mm2. Conclusions: Our study qualitatively and quantitatively demonstrated the response of a mixed type I-II CNV to intravitreal VEGF trap therapy. Although FA remains the gold standard for determining the presence of leakage and OCT easily shows fluid accumulation and its variations, OCT-A offers noninvasive monitoring of the retinal and choriocapillaris microvasculature in patients with CNV, aiding in diagnosis and treatment decisions during follow-up. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2015
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12. Practical guidance for imaging biomarkers in exudative age-related macular degeneration.
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Rispoli, Marco, Cennamo, Gilda, Antonio, Luca Di, Lupidi, Marco, Parravano, Mariacristina, Pellegrini, Marco, Veritti, Daniele, Vujosevic, Stela, and Savastano, Maria Cristina
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MACULAR degeneration , *POLYPOIDAL choroidal vasculopathy , *THREE-dimensional imaging , *OPTICAL coherence tomography , *FLUORESCENCE angiography , *INDOCYANINE green - Abstract
We provide an overview of current macular imaging techniques and identify and describe biomarkers that may be of use in the routine management of macular diseases, particularly exudative age-related macular degeneration (AMD). This perspective includes sections on macular imaging techniques including optical coherence tomography (OCT) and OCT angiography (OCTA), classification of exudative AMD, and biomarkers in structural OCT and OCTA. Fluorescein angiography remains a vital tool for assessing the activity of neovascular lesions, while indocyanine green angiography is the preferred option for choroidal vessel imaging in neovascular AMD. OCT provides a non-invasive three-dimensional visualization of retinal architecture in vivo and is useful in the diagnosis of many imaging biomarkers of AMD-related neovascular lesions, including lesion activity. OCTA is a recent advance in OCT technology that allows accurate visualization of retinal and choroidal vascular flow. OCT and OCTA have led to an updated classification of exudative AMD lesions and provide several biomarkers that help to establish a diagnosis and the disease activity status of neovascular lesions. Individualization of therapy guided by OCT and OCTA biomarkers has the potential to further improve visual outcomes in exudative AMD. Moving forwards, integration of technologically-advanced imaging equipment with AI software will help ophthalmologists to provide patients with the best possible care. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Optical coherence tomography (OCT) angiolytics: a review of OCT angiography quantitative biomarkers.
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Kalra, Gagan, Zarranz-Ventura, Javier, Chahal, Rutvi, Bernal-Morales, Carolina, Lupidi, Marco, and Chhablani, Jay
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OPTICAL coherence tomography , *ANGIOGRAPHY , *BIOMARKERS , *RETINAL diseases - Abstract
Optical coherence tomography angiography (OCTA) provides a non-invasive method to obtain angiography of the chorioretinal vasculature leading to its recent widespread adoption. With a growing number of studies exploring the use of OCTA, various biomarkers quantifying the vascular characteristics have come to light. In the current report, we summarize the biomarkers currently described for retinal and choroidal vasculature using OCTA systems and the methods used to obtain them. Further, we present a critical review of these methods and key findings in common retinal diseases and appraise future directions, including applications of artificial intelligence in OCTA. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Optical Coherence Tomography Angiography in Intermediate and Late Age-Related Macular Degeneration: Review of Current Technical Aspects and Applications
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Matteo Forlini, Riccardo Sacconi, Alessandra Mancini, Rossella D'Aloisio, Rodolfo Mastropasqua, Mario Damiano Toro, Claudio Iovino, Giuseppe Giannaccare, Adriano Carnevali, Livio Vitiello, Enrico Borrelli, Marco Lupidi, Alessio Cerquaglia, Aldo Vagge, Marco Pellegrini, Antonio Di Zazzo, Federico Bernabei, Valentina Gatti, Sabrina Vaccaro, Carnevali, A., Mastropasqua, R., Gatti, V., Vaccaro, S., Mancini, A., D'Aloisio, R., Lupidi, M., Cerquaglia, A., Sacconi, R., Borrelli, E., Iovino, C., Vitiello, L., Toro, M. D., Vagge, A., Bernabei, F., Pellegrini, M., Zazzo, A. D., Forlini, M., Giannaccare, G., Carnevali, Adriano, Mastropasqua, Rodolfo, Gatti, Valentina, Vaccaro, Sabrina, Mancini, Alessandra, D’Aloisio, Rossella, Lupidi, Marco, Cerquaglia, Alessio, Sacconi, Riccardo, Borrelli, Enrico, Iovino, Claudio, Vitiello, Livio, Toro, Mario Damiano, Vagge, Aldo, Bernabei, Federico, Pellegrini, Marco, Di Zazzo, Antonio, Forlini, Matteo, and Giannaccare, Giuseppe
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medicine.medical_specialty ,genetic structures ,posterior segment ,lcsh:Technology ,Age-related macular degeneration, Retinal disease, Optical coherence tomography angiography (OCTA), Macular neovascularization, Posterior segment ,NO ,lcsh:Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,Age related ,medicine ,Age-related macular degeneration ,Macular neovascularization ,Optical coherence tomography angiography (OCTA) ,Posterior segment ,Retinal disease ,General Materials Science ,Instrumentation ,age-related macular degeneration ,lcsh:QH301-705.5 ,030304 developmental biology ,Fluid Flow and Transfer Processes ,0303 health sciences ,business.industry ,lcsh:T ,Process Chemistry and Technology ,General Engineering ,Diagnostic instrument ,Retinal ,Optical coherence tomography angiography ,Macular degeneration ,medicine.disease ,eye diseases ,lcsh:QC1-999 ,Computer Science Applications ,Clinical Practice ,Posterior segment of eyeball ,macular neovascularization ,chemistry ,lcsh:Biology (General) ,lcsh:QD1-999 ,lcsh:TA1-2040 ,030221 ophthalmology & optometry ,optical coherence tomography angiography (OCTA) ,sense organs ,retinal disease ,business ,lcsh:Engineering (General). Civil engineering (General) ,lcsh:Physics - Abstract
Optical coherence tomography angiography (OCTA) is a non-invasive diagnostic instrument that has become indispensable for the management of age-related macular degeneration (AMD). OCTA allows quickly visualizing retinal and choroidal microvasculature, and in the last years, its use has increased in clinical practice as well as for research into the pathophysiology of AMD. This review provides a discussion of new technology and application of OCTA in intermediate and late AMD.
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- 2020
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