1. Optic neuritis in lung adenocarcinoma: A challenging diagnosis.
- Author
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Goudsmit A, Brandao M, Oullai A, Engelman D, Ghorra N, Daif T, Buelens T, and Meert AP
- Subjects
- Humans, COVID-19 Vaccines, Microtubule-Associated Proteins, Nerve Tissue Proteins, Hydrolases, Immunoglobulin G, COVID-19, Optic Neuritis etiology, Optic Neuritis complications, Adenocarcinoma of Lung complications, Adenocarcinoma of Lung diagnosis, Lung Neoplasms complications, Lung Neoplasms diagnosis
- Abstract
Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss., Competing Interests: Conflicts of interest AG: no conflict of interest. MB: travel grant from Roche/GNE and Sanofi, speaker honorarium from Roche/GNE and Janssen (to my institution). AO: no conflict of interest. DE: no conflict of interest. TD: no conflict of interest. NG: no conflict of interest. TB: no conflict of interest. APM: grant from BMS outside the submitted work., (Copyright © 2022 SPLF and Elsevier Masson SAS. All rights reserved.)
- Published
- 2022
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