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Your search keyword '"Jamaluddin, Ruzita"' showing total 3 results
Start Over Author "Jamaluddin, Ruzita" Topic opioid-related disorders
3 results on '"Jamaluddin, Ruzita"'

1. Side Effects of Chronic Methadone Use in Opioid Addiction: A Scoping Review on Hematological Derangements.

Author

Khalid K, Anuar A, Ang WC, and Jamaluddin R

Subjects
Humans, Methadone adverse effects, HIV Infections drug therapy, Opioid-Related Disorders drug therapy, Drug-Related Side Effects and Adverse Reactions
Abstract

Background: Per oral methadone maintenance therapy [MMT] was introduced as part of harm reduction strategy to manage rising numbers of HIV infections caused by intravenous use of illicit drugs., Method: We aim to review published articles related to the side effects of long-term methadone therapy, focusing on hematological derangements in human studies published between 1 January 2000 till 31 January 2021., Results: Our search databases include Web of Science, Scopus, and Medline. Our search yielded 971 articles, of which 55 articles were related to the effects of MMT on various organ systems: cardiovascular [n=12], respiratory [n=1], endocrine [n=10], central nervous system [n=12], neurobehavioral [n=10], gastrointestinal [n=1], and bone [n=1]. There were eight articles specifically related to the hematological side effects of chronic methadone therapy that include [i] immune system hyperactivation, [ii] reduced circulating lymphocytes, and [iii] increased blood viscosity., Conclusion: In view of all foreseeable health risks seen with prolonged methadone therapy, pharmacological modulation is warranted to find a better substitute for managing patients with opioid dependence., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
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2. Methadone Maintenance Treatment for Opioid Dependents: a Retrospective Study

Author

Khalid, Karniza, Ooi, Yit Tyse, Abdul Rashid, Qutbuddin, Mohammad Yusoff, Muhammad Zul Azri, and Jamaluddin, Ruzita

Subjects
Adult, Analgesics, Opioid, Heroin, Illicit Drugs, Organometallic Compounds, Humans, Harm reduction, Illicit drugs, Methadone, Program evaluation, Retrospective studies, Middle Aged, Opioid-Related Disorders, Hepatitis C, Methamphetamine, Retrospective Studies
Abstract

Objectives:To determine the prevalence of continued illicit drug use among people enrolled in methadone maintenance treatment (MMT), the association between hepatitis C status and methadone dosage, and the predictors for illicit drug abstinence during MMT. Methods:Clinical records of active opioid dependents who underwent MMT between 1 January 2007 and 31 March 2021 in Hospital Tuanku Fauziah, Perlis, Malaysia were retrospectively reviewed. Datacollected included baseline demographics, history of illicit drug use, temporal trend in methadone dosage modulation, and co-use of illicit drugs during the MMT.Results:A total of 87 patients (mean age, 43.9 ± 8.33 years) were included. Their mean duration of involvement in MMT was 7.8 ± 3.69 years. The most commonly used drug was heroin (88.5%), followed by kratom (51.7%). Between 2019 and 2021, 61 (70.1%) patients had ceased abusing opioid, but 51 (58.6%) patients continued using any of the illicit drugs. Methamphetamine and amphetamine co-use was most common (n = 12, 37.5%). Hepatitis C status was not associated with the current methadone dose (U = 539.5, p = 0.186) or the highest dose required (t = -0.291, df = 74, p = 0.772). No predictor for illicit drug abstinence during MMT was identified. Methadone dose positively correlated with frequencyof defaulting treatments (r= 0.22, p = 0.042).Conclusion:Among our patients, MMT for opioid dependents cannot sufficiently curb illicit drug use,and there is a shift toward stimulants abuse.

Published
2022

3. Mitragyna speciosa as a Potential Substitute Therapy in Opioid Dependence: A Case Report

Author

Khalid, Karniza, Wong, Jason S.K., and Jamaluddin, Ruzita

Subjects
Mitragyna, opiate alkaloids, opioid-related disorders, illicit drugs, personal narrative
Abstract

Preclinical data have consistently suggested the pharmaceutical potential of kratom (Mitragyna speciosa), including as a substitute therapy in opioid dependence. In this case report, we present a case of a man with a long history of kratom use to help him cope with his opiate withdrawalswhile abstaining from illicit drug use. This is the first published detailed case report highlightingthe potential use of kratom to aid opioid dependence encountered in the clinical setting. Our articleis also supported by literature review with regards to kratom’s safety profile and pharmacologicalpotential.

Published
2022
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