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Your search keyword '"Emilia Donicova"' showing total 2 results
Start Over Author "Emilia Donicova" Topic ophthalmology
2 results on '"Emilia Donicova"'

1. Optical coherence tomography angiography to assess for retinal vascular changes in Neuro-Sjögren

Author

Melanie Haar, Franz Felix Konen, Marten A. Gehlhaar, Irene Oluwatoba-Popoola, Emilia Donicova, Marija Wachsmann, Ahmed Lubbad, Katerina Hufendiek, Amelie Pielen, Bettina Hohberger, Christian Mardin, Stefan Gingele, Nils K. Prenzler, Diana Ernst, Torsten Witte, Carsten Framme, Thomas Skripuletz, Tabea Seeliger, and Anna Bajor

Subjects
Ophthalmology, RE1-994
Abstract

Background: Sjögren’s syndrome is an autoimmune disease characterized by sicca symptoms and various extraglandular manifestations including vasculitis. Neurological involvement occurs frequently (Neuro-Sjögren) and often mimics immune neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP). Objectives: We aim to assess relevant differences in vessel density (VD) in Optical Coherence Tomography Angiography (OCTA) in those diseases to use it as an easily available diagnostic tool. Design: Prospective, monocentric pilot-study. Methods: OCTA (Heidelberg Engineering OCT SPECTRALIS) of the superficial vascular plexus, intermediate capillary plexus (ICP) and deep capillary plexus (DCP) of the retina was prospectively performed in Neuro-Sjögren, age-matched CIDP patients ( n = 31, each), and healthy controls ( n = 30). Vessel density (VD) and foveal avascular zone (FAZ) was measured with Erlangen Angio Tool. Results: Significantly lower VD were found for the DCP and ICP in Neuro-Sjögren and CIDP patients compared to healthy controls ( p = 0.0002 and

Published
2024
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2. The flicker response of venous oxygen saturation is significantly reduced in the early and late stages of age-related macular degeneration

Author

Martin Hammer, Emilia Donicova, Regine Augsten, and Lisa Ramm

Subjects
Male, medicine.medical_specialty, End stages, genetic structures, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Oxygen Consumption, Ophthalmology, Age related, 0502 economics and business, medicine, Humans, Oximetry, Oxygen saturation (medicine), Aged, Oxygen supply, business.industry, 05 social sciences, Healthy subjects, Retinal Vessels, Retinal, Macular degeneration, medicine.disease, eye diseases, Sensory Systems, Oxygen, chemistry, Regional Blood Flow, 030221 ophthalmology & optometry, Wet Macular Degeneration, Venous oxygen saturation, 050211 marketing, Female, sense organs, business, Photic Stimulation
Abstract

Retinal oxygen saturation (SO2) during flicker light stimulation was measured non-invasively in humans with age-related macular degeneration (AMD). Furthermore, the differences between early and late stages of AMD were evaluated. In 60 eyes of 45 AMD patients (74 ± 8.3 years) and 23 eyes of 23 healthy controls (73.4 ± 7.4 years), the SO2 of arterioles and venules was measured with the oximetry module of the Retinal Vessel Analyzer. Arterial SO2, venous SO2 and arteriovenous SO2 difference at baseline and with the flicker were assessed and compared with controls. From the difference between the arteriovenous SO2 under flicker stimulation and at baseline, the parameter delta av. Diff was calculated. Subgroup analyses of non-exudative (dry) AMD, exudative (wet) AMD and their end stages, geographic atrophy (GA) and disciform scar (DS) were performed. In comparison with healthy subjects (mean − 4.90, CI [− 6.32, − 3.43]), the parameter delta av. Diff was significantly reduced in all AMD patients (mean − 2.20, CI − 3.15, −1.23, p = 0.003), dry AMD (mean − 1.97, CI − 3.31, −0.63, p = 0.013) and wet AMD (mean − 2.35, CI − 3.50, − 1.19, p = 0.025). The comparison between wet and dry AMD revealed no significant results (p = 1). The comparison between AMD subgroups and healthy controls (median (IQR) − 4.29 (− 8.32; − 2.42) %) showed significant differences in non-neovascular (early dry AMD) (median (IQR) − 2.43 (− 4.59; − 0.74) %, p = 0.038), GA (median (IQR) 0.10 (− 4.02; 3.15) %, p = 0.019) and DS (median (IQR) − 1.67 (− 3.52; − 0.12) %, p = 0.03). A nearly significant reduction was observed in exudative (early wet) AMD (median (IQR) − 2.71 (− 5.84; − 0.2) %, p = 0.055). Minimal, not statistically significant differences of delta av. Diff were found between AMD subgroups. None of the baseline parameters was significantly different between patients and healthy controls, even after flicker light stimulation. Non-invasive retinal oximetry with flicker light stimulation seems to be a suitable method to study the pathogenetic mechanisms of AMD. The mathematically derived parameter delta av. Diff appears to be more sensitive than arteriovenous SO2 difference. Results suggest that the regulation of retinal oxygen supply, oxygen consumption or both is impaired in AMD.

Published
2019

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