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STUDY QUESTION How efficacious is transplantation of ovarian cortex previously exposed to chemotherapy? SUMMARY ANSWER Prior exposure to chemotherapy did not disrupt the function of cryopreserved ovarian tissue after transplantation. WHAT IS KNOWN ALREADY Ovarian tissue cryopreservation (OTC) followed by ovarian tissue transplantation (OTT) is an efficacious technique for restoration of female fertility. At least 130 children have been born following this procedure. To date, little is known about the efficacy of OTT in patients exposed to cancer chemotherapy prior to OTC. STUDY DESIGN, SIZE, DURATION This study evaluates the recovery of ovarian function and fertility in 31 consecutive patients who had received OTT, between 2005 and 2015. PARTICIPANTS/MATERIALS, SETTING, METHODS Thirty one patients, wanting children, were transplanted with autologous ovarian cortex, among which 22 patients (71%) had been exposed to chemotherapy before OTC. Recovery of ovarian function was considered total once menstruation occurred. Ovarian function recovery (OFR), ovarian graft survival, and incidence of pregnancy were related to previous chemotherapy exposure, type of chemotherapy and graft characteristics (number of grafted fragments and follicular density). MAIN RESULTS AND ROLE OF CHANCE The amount of ovarian tissue collected was the only parameter to show any significant change between patients with versus without previous chemotherapy. At 1 year after OTT, the cumulative incidence of OFR was 83% (93% in patients exposed to chemotherapy and 67% in others (P = 0.14)). A low follicular density (

Aim: Tumor volume (TV) is an emerging quantitative imaging biomarker that is expected to overcome some limitations of the longest axial diameter measurements in objective response evaluation criteria. Several features of the TV biomarker are still investigated, notably its application to hepatic lesions where the minimum detectable change has not been established. Another undocumented aspect concerns the kind of hepatic lesions that can be reliably quantified. This study aims at measuring inter reader variability of hepatic TV assessments on computed tomography. Methods: 82 patients enrolled from four different hospitals were included in our retrospective study. A total of 142 target lesions that included 32 hepatocellular carcinomas (HCC) were analysed. Each of the three involved experienced radiologists performed volumetric measurements of all lesions using a semi-automated segmentation system allowing manual corrections. Each reader documented lesion complexity when found relevant. Bland Altman analysis was performed between pairs of readers. Wilcoxon test reported association between inter-reader relative difference and factors as pathology, lesion pattern, localisation or phase enhancement. Results: 39 out of 142 (27.5%) lesions were reported as complex and unsuitable for quantification by, at least, two radiologists. 14 out of 103 (13.6%) lesions that were segmented by all readers were inconsistently interpreted, generating a variability in the range of [100%; 190%]. Association was found between variability and disease (p=0.014) HCC/non-HCC. Considering the subset of consistent segmentations, the Limit of Agreement by each pair of readers was: 49.1%, 54.9% and 53.1%. No association was found regarding factors as subcapsular/isolated (p=0.71), portal/arterial scans (p=0.58), hypo/hyper attenuated lesions (p=0.37) or diffuse/focal lesions (p=0.21). Conclusions: Our results indicate that volumetry was not applicable to a subset of lesions and that HCC assessments featured higher variability. Approximate bounds for minimal detectable change of hepatic TV are found in the range of [45%; 55%]. We did not identify evidence of significant associations between variability and specific imaging or lesion features. Disclosure: All authors have declared no conflicts of interest.