1. The effects of rabeprazole on parietal cells and enterochromaffin-like cells in rats: a comparison with omeprazole.
- Author
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Tari A, Kawano M, Kodama K, Yonei Y, Okahara S, Haruma K, Sumii K, and Kajiyama G
- Subjects
- 2-Pyridinylmethylsulfinylbenzimidazoles, Animals, Drug Therapy, Combination, Gastrins analysis, Histamine analysis, Male, Models, Animal, Rabeprazole, Rats, Rats, Wistar, Stomach chemistry, Stomach cytology, Anti-Ulcer Agents pharmacology, Benzimidazoles pharmacology, Enterochromaffin-like Cells drug effects, Omeprazole pharmacology, Parietal Cells, Gastric drug effects, Stomach drug effects
- Abstract
Background: We investigated the effects of rabeprazole compared with those of omeprazole on enterochromaffin-like cells and parietal cells in rats., Methods: Rabeprazole or omeprazole was administered for 7 days by intraperitoneal injection (100 mg/kg or 20mg/kg once a day) and the serum gastrin concentration, the antral density of G cells and D cells, fundic histamine content, fundic H+, K+-ATPase mRNA level, and parietal cell morphology were determined., Results: Both rabeprazole and omeprazole inhibited gastric acid secretion and increased the intragastric pH to over 6.5, as well as causing a marked increase in the serum gastrin concentration. The serum gastrin level was lower with rabeprazole treatment than with omeprazole treatment at both doses. Also, the antral G-cell density was higher with omeprazole than with rabeprazole, while the increase in both the histamine content and the H+, K-ATPase mRNA level in the fundic mucosa was higher with omeprazole treatment at both doses, with the difference being significant at 100 mg/kg. Ultrastructural examination indicated that the stimulation of parietal cells by omeprazole was stronger than that by rabeprazole., Conclusions: Rabeprazole treatment does not drive enterochromaffin-like cells and parietal cells as strongly as omeprazole treatment despite its potent acid suppressive effect, suggesting that it represents a new generation of proton pump inhibitors.
- Published
- 2002
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