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Start Over Author "Chwalinski, T." Topic oligodeoxyribonucleotides

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1. Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.

Author

Clark GR, Brown DG, Sanderson MR, Chwalinski T, Neidle S, Veal JM, Jones RL, Wilson WD, Zon G, and Garman E

Subjects
Base Sequence, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Nucleic Acid Conformation, Solutions, X-Ray Diffraction, Oligodeoxyribonucleotides chemistry
Abstract

A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.

Published
1990
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