1. Abnormal functional connectivity of the core olfactory network in patients with chronic rhinosinusitis accompanied by olfactory dysfunction
- Author
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Yao Ma, Jian Jiang, Ying Wu, Jiaxin Xiong, Huiting Lv, Jiahao Li, Hongmei Kuang, Xiaofeng Jiang, and Yeyuan Chen
- Subjects
functional connectivity ,olfactory network ,chronic rhinosinusitis ,olfactory dysfunction ,functional magnetic resonance imaging ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
ObjectiveTo review and analyze the functional connectivity (FC) abnormalities in the brain olfactory network (ON) of patients with chronic rhinosinusitis with olfactory dysfunction (CRSwOD) and explore the relationship between these FC abnormalities and olfactory dysfunction, providing clues to the neurophysiological mechanisms underlying CRSwOD.MethodsFC analysis on the ON of patients with CRSwOD and patients with chronic rhinosinusitis without olfactory dysfunction (CRSsOD) identified the regions of the ON with abnormal FC in CRSwOD patients, and the correlation between abnormal FC and clinical scales for chronic rhinosinusitis was analyzed.Results(1) Compared with the CRSsOD group, CRSwOD patients showed decreased FC between the bilateral orbitofrontal cortex (OFC) and the right middle frontal gyrus, (2) Receiver operating characteristic (ROC) curve analysis revealed that the FC value between the right middle frontal gyrus and the left OFC (area under the curve (AUC) = 0.852, sensitivity: 0.821, specificity: 0.800, p
- Published
- 2023
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