51. Increased Tear Film Osmolarity in Systemic Lupus Erythematosus.
- Author
-
Duru, Necati, Altinkaynak, Hasan, Uysal, Betul Seher, Duru, Zeynep, Can, Mehmet Erol, Erten, Sukran, Yuksel, Nilay, and Kalkan Akcay, Emine
- Subjects
SYSTEMIC lupus erythematosus ,OSMOLAR concentration ,LABS on a chip ,DIAGNOSTIC imaging ,DRY eye syndromes ,DIAGNOSIS ,TEARS (Body fluid) ,CROSS-sectional method ,CASE-control method ,DISEASE complications - Abstract
Purpose: To evaluate tear film osmolarity in patients with systemic lupus erythematosus (SLE).Methods: A total of 55 eyes from 55 patients with SLE and 47 eyes from 47 age- and gender-matched healthy individuals were included in this study. Tear film osmolarity was evaluated with a lab-on-a-chip technique (TearLab; TearLab Corporation, San Diego, CA) in SLE patients in comparison with healthy individuals, and results were correlated to clinically available diagnostic tests for dry eye, such as tear film break-up time (BUT), Schirmer's test, and Ocular Surface Disease Index (OSDI).Results: The mean tear film osmolarity in the SLE patients and healthy individuals was 306.02 ± 13.27 mOsm/L and 300.74 ± 9.11 mOsm/L, respectively, which made for a statistically significant difference (p = 0.020). In the SLE group, tear film osmolarity was negatively correlated with the Schirmer's test score and the BUT value (r = -0.295 p = 0.029 and r = 0.347 p = 0.009, respectively), whereas tear film osmolarity was not correlated with OSDI score (r = -0.182 p = 0.183).Conclusions: This study revealed that tear film hyperosmolarity and abnormal tear film function are associated with SLE. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF