1. Applied Force Alters Sensorineural and Peripheral Vascular Function in a Rat Model of Hand-Arm Vibration Syndrome.
- Author
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Krajnak K, Warren C, Xu X, Chapman P, Waugh S, Boots T, Welcome D, and Dong R
- Subjects
- Rats, Animals, Vibration adverse effects, Hand-Arm Vibration Syndrome, Occupational Diseases, Occupational Exposure
- Abstract
Objective: This study described the effects of applied force (grip) on vascular and sensorineural function in an animal model of hand-arm vibration syndrome (HAVS)., Methods: Rat tails were exposed to 0, 2, or 4 N of applied force 4 hr/d for 10 days. Blood flow and sensitivity to transcutaneous electrical stimulation and pressure were measured., Results: Applied force increased blood flow but reduced measures of arterial plasticity. Animals exposed to force tended to be more sensitive to 250-Hz electrical stimulation and pressure applied to the tail., Conclusions: Effects of applied force on blood flow and sensation are different than those of vibration. Studies examining co-exposures to force and vibration will provide data that can be used to determine how these factors affect risk of workers developing vascular and sensorineural dysfunction (ie, HAVS)., Competing Interests: Krajnak, Warren, Xu, Chapman, Waugh, Boots, Welcome, and Dong have no relationships/conditions/circumstances that present potential conflict of interest., (Copyright © 2023 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.)
- Published
- 2024
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