Search

Background: Obesity predisposes an individual to numerous risk factors for cardiovascular diseases. Inflammation, reported as a link between obesity and cardiovascular disease, contributes to the development of atherosclerosis., Objectives: The aim of our study was to assess the relationship between lipid parameters, low grade inflammation and metabolic syndrome in a sample of obese Moroccan adults with or without metabolic syndrome (MetS)., Patients & Methods: Our study included 235 obese patients, mean aged 53.30 ± 9.73 years, with or without MetS. Our data included anthropometric measurements, lipoprotein and apolipoproteins profiles and several lipid ratios., Results: In patients with MetS, lipoprotein profile alterations and low-grade inflammation were observed. Lipid ratios were better predictors of cardiovascular risk than lipids alone because of their relative associations with lipoproteins and apolipoproteins., Conclusion: Our study shows that Moroccan obese adults with MetS have altered lipoproteins profiles and suffer from low-grade inflammation. Indeed, we have detected a high level of small dense LDL particles and HDL particles defectiveness. Hence, we propose that risk management of cardiovascular events should be based on lipoprotein ratios rather than lipids alone. Treatments should also take into account inflammatory markers and LDL heterogeneity.

Objectives: Our study aimed to study the impact of obesity and metabolic syndrome (MetS) on lipoprotein profiles and cardiovascular risk through lipid ratios and atherogenic index of plasma (AIP) in Moroccan women., Methods: Our study included 240 Moroccan women, aged 53.31 +/- 8.51 years, divided into three groups: controls (group 1, n = 80), obese without MetS (group 2, n = 80) and obese with MetS (group 3, n = 80). Anthropometric and lipid measurements were taken and specific lipid ratios assessed, as well as Non-HDL cholesterol (Non-HDL-C) and atherogenic index of plasma (ALP)., Results: Group 2 presented similar lipoprotein profiles compared with group 1. Group 3 had higher triglyceride (TG) levels than group 1, which, in turn, increased HDL and AIP values. Dyslipidemia in group 3 was demonstrated by higher TG levels, lipid ratios and AIP and lower HDL-C levels compared with group 2. All of these abnormalities are responsible for elevations of risks of cardiovascular diseases. Closer associations were found between cardiovascular risk and lipid ratios and AIP than lipids alone., Conclusion: Our study confirms that MetS affects the serum lipoprotein profile of obese women. Lipid ratios, non HDL-C and AIP remain useful tools for the diagnosis and prognosis of cardiovascular disease by their associations with lipid parameters and their high predictive values.