Search

Polyphenols from cambuci (CBC) (Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Polyphenol-rich cagaita (Eugenia dysenterica DC.) extracts (PCE) have previously shown to prevent body weight and adiposity induced by high-fat/high-sucrose (HFS) diet. Whether PCE also exerts protective effects in already developed obesity is unknown. In order to test this hypothesis, male C57BL/6J obese mice (previously feed with a HFS diet for six weeks) were treated with PCE at two doses, 7mg gallic acid equivalent (GAE)/kg body weight (PCE I group), and 14mg GAE/kg body weight (PCE II group) or water (HFS and Chow groups) by oral gavage for eight weeks. PCE did not affect body weight and adiposity of obese mice. However, PCE did protect against dyslipidemia, fasting hyperglycemia, and glucose intolerance, and attenuated both hepatic gluconeogenesis and inflammation as observed by the expression of tumor necrosis factor-α and transcriptional factor NF-κB. These results indicate that PCE improves glucose homeostasis of obese mice by attenuating hepatic gluconeogenesis and inflammation., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Cagaita ( Eugenia dysenterica DC.) is a Brazilian Cerrado biome tree, whose fruit and leaves are used as alternative medicine by local communities to treat diarrhea, diabetes, and jaundice. Phenolic compounds from cagaita fruit have demonstrated in vitro antioxidant potential and inhibitory actions toward the activity of enzymes involved in carbohydrate metabolism. Herein, we evaluated whether administration of phenolic-rich extracts from cagaita (CGT) affects obesity and its metabolic complications induced by the intake of a high-fat high-sucrose (HF/HS) diet during an eight-week period. Four groups of male C57BL/6J mice ( n = 9–10 per group) fed either with a chow diet (Chow group) or an HF/HS diet were daily treated by gavage with water or CGT at doses of 7 and 14 mg gallic acid equivalent (GAE)/kg body weight (HF/HS, CGT7, and CGT14 groups). Treatment with both doses of CGT attenuated the increase in body weight gain and fat accumulation induced by the intake of an HF/HS diet without affecting food intake. Such protection from a diet-induced obesity by CGT was associated with the attenuation of fasting hyperglycemia, hypertriglyceridemia, and hypercholesterolemia, with no effect on glycemic control post-glucose challenge. Furthermore, CGT treatment also improved plasma antioxidant status. The fecal triglycerides excretion was increased by CGT phenolics at both studied doses. No significant alteration in liver glycogen and total cholesterol content was noted among the groups, but a significant decrease in liver triacylglycerol was found in the CGT7 group when compared to the HF/HS group. These results indicate that phenolics from cagaita may play an important role in the prevention of obesity and its associated abnormalities, and also point out their potential for the development of new applications and complementary strategies in therapeutic alternatives. [ABSTRACT FROM AUTHOR]

[Display omitted] • Polyphenols from jaboticaba (PEJ) were evaluated in mice with diet-induced obesity. • PEJ decreased the body weight gain, adipocyte hypertrophy and inflammation. • PEJ reduced hyperglycemia and insulin resistance and modulated the AKT/mTOR pathway. • Hepatic steatosis and inflammation were ameliorated in PEJ-treated animals. • PEJ increased energy expenditure of supplemented obese animals. Obesity is a critical public health problem worldwide that has been associated to non-communicable diseases (NCD), such as type 2 diabetes (T2DM), non-alcoholic fatty lipid diseases (NAFLD) and inflammatory diseases. Polyphenols from several food sources have been studied as one option against these health problems. Sabara jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian berry rich in ellagic acid derivatives and anthocyanins. Here we investigated the effects of a phenolic-rich extract from Sabara jaboticaba (PEJ) in a diet-induced obesity animal model. PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) and 100 mg GAE/kg BW, were administered by daily gavage to obese C57BL/6J mice for 14 weeks. PEJ prevented the excessive body weight and adiposity, adipocyte hypertrophy, inflammation, hyperglycemia, glucose intolerance, insulin resistance, hypercholesterolemia, and hepatic lipid accumulation, as well as increased energy expenditure. In conclusion, polyphenols from Sabara jaboticaba presented several powerful therapeutic properties relevant for fighting obesity and associated health problems. [ABSTRACT FROM AUTHOR]