41 results on '"Barrett, A. E."'
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2. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
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Whitlock, Gary, Lewington, Sarah, Sherliker, Paul, Clarke, Robert, Emberson, Jonathan, Halsey, Jim, Qizilbash, Nawab, Collins, Rory, Peto, Richard, Lewington, S, MacMahon, S, Peto, R, Aromaa, A, Baigent, C, Carstensen, J, Chen, Z, Clarke, R, Collins, R, Duffy, S, Kromhout, D, Neaton, J, Qizilbash, N, Rodgers, A, Tominaga, S, Toernberg, S, Tunstall-Pedoe, H, Whitlock, G, Chambless, L, De Backer, G, De Bacquer, D, Kornitzer, M, Whincup, P, Wannamethee, SG, Morris, R, Wald, N, Morris, J, Law, M, Knuiman, M, Bartholomew, H, Smith, G Davey, Sweetnam, P, Elwood, P, Yarnell, J, Kronmal, R, Sutherland, S, Keil, J, Jensen, G, Schnohr, P, Hames, C, Tyroler, A, Knekt, P, Reunanen, A, Tuomilehto, J, Jousilahti, P, VArtiainen, E, Puska, P, Kuznetsova, Tatiana, Richart, Tom, Staessen, Jan A, Thijs, Lutgarde, Jorgensen, T, Thomsen, T, Sharp, D, Curb, JD, Iso, H, Sato, S, Kitamura, A, Naito, Y, Benetos, A, Guize, L, Goldbourt, U, Tomita, M, Nishimoto, Y, Murayama, T, Criqui, M, Davis, C, Hart, C, Hole, D, Gillis, C, Jacobs, D, Blackburn, H, Luepker, R, Eberly, L, Cox, C, Levy, D, D'Agostino, R, Silbershatz, H, Tverdal, A, Selmer, R, Meade, T, Garrow, K, Cooper, J, Speizer, F, Stampfer, M, Menotti, A, Spagnolo, A, Tsuji, I, Imai, Y, Ohkubo, T, Hisamichi, S, Haheim, L, Holme, I, Hjermann, I, Leren, P, Ducimetiere, P, Empana, J, Jamrozik, K, Broadhurst, R, Assmann, G, Schulte, H, Bengtsson, C, Bjoerkelund, C, Lissner, L, Sorlie, P, Garcia-Palmieri, M, Barrett-Conner, E, Langer, R, Nakachi, K, Imai, K, Fang, X, Buzina, R, Nissinen, A, Aravanis, C, Dontas, A, Kafatos, A, Adachi, H, Toshima, H, Imaizumi, T, Nedeljkovic, S, Ostojic, M, CHen, Z, Nakayama, T, Yoshiike, N, Yokoyama, T, Date, C, Tanaka, H, Keller, J, Bonaa, K, Arnesen, E, Rimm, E, Gaziano, M, Buring, JE, Hennekens, C, Tornberg, S, Shipley, M, Leon, D, Marmot, M, Emberson, J, Halsey, J, Palmer, A, Parish, S, and Sherliker, P
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Male ,obesity ,Nutrition and Disease ,Respiratory Tract Diseases ,Myocardial Ischemia ,individual data ,030204 cardiovascular system & hematology ,Overweight ,Body Mass Index ,0302 clinical medicine ,blood-pressure ,Cause of Death ,Voeding en Ziekte ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,risk ,Cause of death ,Aged, 80 and over ,Hazard ratio ,Articles ,General Medicine ,Middle Aged ,3. Good health ,Stroke ,Female ,medicine.symptom ,Adult ,medicine.medical_specialty ,Waist ,abdominal adiposity ,united-states ,03 medical and health sciences ,vascular mortality ,Internal medicine ,Humans ,korean men ,Mortality ,Aged ,VLAG ,business.industry ,Anthropometry ,medicine.disease ,Obesity ,Surgery ,randomized-trials ,coronary-heart-disease ,business ,Body mass index - Abstract
Summary Background The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studies Collaboration aimed to investigate these associations by sharing data from many studies. Methods Collaborative analyses were undertaken of baseline BMI versus mortality in 57 prospective studies with 894 576 participants, mostly in western Europe and North America (61% [n=541 452] male, mean recruitment age 46 [SD 11] years, median recruitment year 1979 [IQR 1975–85], mean BMI 25 [SD 4] kg/m2). The analyses were adjusted for age, sex, smoking status, and study. To limit reverse causality, the first 5 years of follow-up were excluded, leaving 66 552 deaths of known cause during a mean of 8 (SD 6) further years of follow-up (mean age at death 67 [SD 10] years): 30 416 vascular; 2070 diabetic, renal or hepatic; 22 592 neoplastic; 3770 respiratory; 7704 other. Findings In both sexes, mortality was lowest at about 22·5–25 kg/m2. Above this range, positive associations were recorded for several specific causes and inverse associations for none, the absolute excess risks for higher BMI and smoking were roughly additive, and each 5 kg/m2 higher BMI was on average associated with about 30% higher overall mortality (hazard ratio per 5 kg/m2 [HR] 1·29 [95% CI 1·27–1·32]): 40% for vascular mortality (HR 1·41 [1·37–1·45]); 60–120% for diabetic, renal, and hepatic mortality (HRs 2·16 [1·89–2·46], 1·59 [1·27–1·99], and 1·82 [1·59–2·09], respectively); 10% for neoplastic mortality (HR 1·10 [1·06–1·15]); and 20% for respiratory and for all other mortality (HRs 1·20 [1·07–1·34] and 1·20 [1·16–1·25], respectively). Below the range 22·5–25 kg/m2, BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer. These inverse associations were much stronger for smokers than for non-smokers, despite cigarette consumption per smoker varying little with BMI. Interpretation Although other anthropometric measures (eg, waist circumference, waist-to-hip ratio) could well add extra information to BMI, and BMI to them, BMI is in itself a strong predictor of overall mortality both above and below the apparent optimum of about 22·5–25 kg/m2. The progressive excess mortality above this range is due mainly to vascular disease and is probably largely causal. At 30–35 kg/m2, median survival is reduced by 2–4 years; at 40–45 kg/m2, it is reduced by 8–10 years (which is comparable with the effects of smoking). The definite excess mortality below 22·5 kg/m2 is due mainly to smoking-related diseases, and is not fully explained. Funding UK Medical Research Council, British Heart Foundation, Cancer Research UK, EU BIOMED programme, US National Institute on Aging, and Clinical Trial Service Unit (Oxford, UK).
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- 2009
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3. Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?
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Kim, CS, Kim, SK, Araneta, MRG, Lee, EJ, Barrett-Connor, E, and Huh, KB
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Carotid Artery Diseases ,Male ,Clinical Sciences ,Intra-Abdominal Fat ,Visceral fat thickness ,Cardiovascular ,Carotid Intima-Media Thickness ,Body Mass Index ,Cohort Studies ,Endocrinology & Metabolism ,Risk Factors ,Clinical Research ,Carotid atherosclerosis ,Republic of Korea ,Type 2 diabetes mellitus ,Diabetes Mellitus ,Prevalence ,Humans ,Urban ,Abdominal ,cardiovascular diseases ,Obesity ,Metabolic and endocrine ,Aged ,Adiposity ,Nutrition ,Cancer ,Special ,Diabetes ,Middle Aged ,Atherosclerosis ,Hospitals ,cardiovascular system ,Disease Progression ,Female ,Insulin Resistance ,Waist Circumference ,Diabetic Angiopathies ,Type 2 - Abstract
© 2015. Aims: Type 2 diabetes mellitus (T2DM) and visceral obesity are associated with each other and with cardiovascular diseases. We determined whether increased visceral adiposity without weight gain was associated with sex-specific accelerated carotid atherosclerosis in South Koreans with T2DM. Methods: From 2003 to 2012, we recruited 280 participants with T2DM for the Seoul Metabolic Syndrome cohort who had body weight, visceral fat thickness (VFT), and carotid intima-media thickness (CIMT) measured at intervals of 2. years. According to VFT change, sex-specific quartiles of clinical characteristics and changes of CIMT were determined. Logistic regression models predicted the odds of the progression of CIMTs in each quartile. Results: During 2. years of observation, VFTs fell by 5.2. ±. 13.5. mm in men (P
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- 2015
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4. Association of breastfeeding with postmenopausal visceral adiposity among three racial/ethnic groups
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Armenta, RF, Kritz-Silverstein, D, Wingard, D, Laughlin, GA, Wooten, W, Barrett-Connor, E, and Araneta, MR
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Ethnic Groups ,and over ,Intra-Abdominal Fat ,Body Mass Index ,Endocrinology & Metabolism ,Risk Factors ,Ethnicity ,80 and over ,Humans ,Obesity ,Child ,Nutrition ,Retrospective Studies ,Aged ,Adiposity ,Pediatric ,Continental Population Groups ,Prevention ,Racial Groups ,nutritional and metabolic diseases ,Middle Aged ,Prognosis ,United States ,Radiography ,Postmenopause ,Breast Feeding ,Female ,Follow-Up Studies - Abstract
© 2014 The Obesity Society. Objective We examined the association between breastfeeding and postmenopausal visceral adiposity. Methods Participants were community-dwelling women aged 55-80 from the Caucasian Rancho Bernardo Study, the Filipino Women's Health Study, and the Health Assessment Study of African-American Women who had visceral adipose tissue (VAT) measurements by computed tomography between 2000 and 2002. Linear regression was used to determine the association between average breastfeeding duration per child and VAT. Results In Caucasian, Filipino, and African-American women, average number of live births was 3, 4, and 3; average breastfeeding duration was 4.3, 1.8, and 5.1 months, respectively. Filipino women had more live births, were more likely to breastfeed, and breastfed shorter durations. African-American women had lower VAT, despite higher subcutaneous adipose tissue (SAT), BMI, and waist girth. Women who breastfed >3 months on average had 8.8 cm3lower VAT than women who breastfed ≤3 months, independent of covariates. Women who initiated breastfeeding had lower BMI and waist girth than those who did not, but they did not differ by VAT unless they breastfed >3 months. Associations were independent of race/ethnicity. Conclusions Results suggest breastfeeding initiation is associated with reduced BMI and smaller waist girth, and breastfeeding >3 months is associated with lower postmenopausal VAT.
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- 2015
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5. Seasonal variation in fasting plasma glucose levels in man
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Suarez, L. and Barrett-Connor, E.
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- 1982
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6. Similarity in Percent Body Fat between White and Vietnamese Women: Implication for a Universal Definition of Obesity
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Ho-Pham, LT, Lai, TQ, Nguyen, ND, Barrett-Connor, E, and Nguyen, TV
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Aged, 80 and over ,Asian Continental Ancestry Group ,Matched-Pair Analysis ,European Continental Ancestry Group ,Middle Aged ,California ,Body Mass Index ,Endocrinology & Metabolism ,Cross-Sectional Studies ,Vietnam ,Reference Values ,Humans ,Body Fat Distribution ,Female ,Obesity ,Aged ,Adiposity - Abstract
© 2010 North American Association for the Study of Obesity (NAASO). It has been widely assumed that for a given BMI, Asians have higher percent body fat (PBF) than whites, and that the BMI threshold for defining obesity in Asians should be lower than the threshold for whites. This study sought to test this assumption by comparing the PBF between US white and Vietnamese women. The study was designed as a comparative cross-sectional investigation. In the first study, 210 Vietnamese women ages between 50 and 85 were randomly selected from various districts in Ho Chi Minh City (Vietnam). In the second study, 419 women of the same age range were randomly selected from the Rancho Bernardo Study (San Diego, CA). In both studies, lean mass (LM) and fat mass (FM) were measured by dual-energy X-ray absorptiometry (DXA) (QDR 4500; Hologic). PBF was derived as FM over body weight. Compared with Vietnamese women, white women had much more FM (24.8 ± 8.1 kg vs. 18.8 ± 4.9 kg; P < 0.0001) and greater PBF (36.4 ± 6.5% vs. 35.0 ± 6.2%; P = 0.012). However, there was no significant difference in PBF between the two groups after matching for BMI (35.1 ± 6.2% vs. 35.0 ± 5.7%; P = 0.87) or for age and BMI (35.6 ± 5.1% vs. 35.8 ± 5.9%; P = 0.79). Using the criteria of BMI ≥30, 19% of US white women and 5% of Vietnamese women were classified as obese. Approximately 54% of US white women and 53% of Vietnamese women had their PBF >35% (P = 0.80). Although white women had greater BMI, body weight, and FM than Vietnamese women, their PBF was virtually identical. Further research is required to derive a more appropriate BMI threshold for defining obesity for Asian women.
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- 2010
7. The association between prepregnancy obesity and screening positive for postpartum depression.
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LaCoursiere, D. Y., Barrett-Connor, E., O'Hara, M. W., Hutton, A., and Varner, M. W.
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HIGH-risk pregnancy , *OBESITY , *POSTPARTUM depression , *BODY mass index , *COHORT analysis , *URBAN hospitals - Abstract
Please cite this paper as: LaCoursiere D, Barrett-Connor E, O’Hara M, Hutton A, Varner M. The association between prepregnancy obesity and screening positive for postpartum depression. BJOG 2010;117:1011–1018. Objective To describe the association between reported prepregnancy body mass index (BMI) and screening positive for depression. Design Cohort study. Setting Four urban hospitals in Utah, USA. Population Women delivering a term, singleton, live-born infant at one of four urban hospitals in Utah in the period 2005–2007. Methods Women were enrolled immediately postpartum. Demographic, anthropometric, stressors, psychiatric, and medical/obstetric and family-history data were obtained. Prepregnancy height, weight, and pregnancy weight gain were self-reported. The primary exposure variable, prepregnancy BMI, was calculated. Women were stratified into the six World Health Organization BMI categories (underweight, normal weight, pre-obese, or obese class 1–3). Main outcome measure At 6–8 weeks postpartum, women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS). The primary outcome measure was a prespecified EPDS score of ≥12. Results Among the 1053 women studied, 14.4% of normal weight women screened positive for postpartum depression. This proportion was greater in women classed as underweight (18.0%, n = 11), pre-obese (18.5%, n = 38), obese class 1 (18.8%, n = 16), obese class 2 (32.4%, n = 11), and obese class 3 (40.0%, n = 8) ( P < 0.01). Controlling for demographic, psychological, and medical/obstetric factors, prepregnancy class-2 (aOR 2.87, 95% CI 1.21–6.81) and class-3 (aOR 3.94, 95% CI 1.38–11.23) obesity remained strongly associated with screening positive for postpartum depression, compared with women of normal weight. Conclusions Self-reported prepregnancy obesity may be associated with screening positive for depression when measured postpartum. [ABSTRACT FROM AUTHOR]
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- 2010
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8. Obesity, estrone, and coronary artery disease in postmenopausal women
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Silva, T.C.B.F., Barrett-Connor, E., Ramires, J.A.F., and Mansur, A.P.
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NUTRITION disorders , *BLOOD circulation disorders , *METABOLIC disorders , *DIABETES , *CLINICAL medicine , *ESTROGEN - Abstract
Abstract: Objectives: The link between obesity and endogenous estrogen with coronary artery disease (CAD) in postmenopausal women is uncertain. In this prospective study we analyzed the association of body mass index (BMI) and blood levels of estrone in postmenopausal women with known CAD or with a high risk factor score for CAD. Methods: Participants were 251 female clinic patients aged 50–90 years who were postmenopausal and not using estrogen therapy. Clinical and behavioral characteristics and fasting blood for estrone and heart disease risk factors were collected at baseline, and again at 1 and 2 years. Women were grouped according to their BMI (kg/m2) as normal (18.5≤BMI<25), overweight (25≤BMI<30) or obese (BMI ≥30), and by low and high estrone levels (<15 and ≥15pg/mL, respectively). Fatal and nonfatal events were recorded for 2 years after baseline. Results: Women with a low estrone level were older, thinner, and had less hypertension, diabetes, and lower triglyceride and glucose levels. BMI was positively associated with estrone levels, hypertension, and diabetes and inversely associated with HDL cholesterol. There were 14 deaths, 8 attributed to CAD. The Kaplan–Meier survival curve showed a nonsignificant trend (p =0.074) of greater all cause mortality in women with low estrone levels (<15mL). In this model, adjusted for BMI, age [OR=1.08; p =0.03], C-reactive protein [OR=1.24; p =0.024] and hypertension [OR=6.22; p =0.003] were independent predictors of all cause mortality. Conclusions: Postmenopausal women with low estrone levels (<15pg/mL) had a trend for increased mortality over the next 2 years. Larger, longer studies are needed. [Copyright &y& Elsevier]
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- 2008
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9. Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells.
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Hoda, M. R., Keely, S. J., Bertelsen, L. S., Junger, W. G., Dharmasena, D., and Barrett, K. E.
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LEPTIN ,CANCER cells ,COLON cancer ,OBESITY ,MITOGEN-activated protein kinases - Abstract
Background: Obesity is associated with increased levels of leptin. The mitogenic actions of leptin have been identified in various cell types. Because obesity may be a risk factor for colonic cancer, the proliferative and antiapoptotic effects of leptin on colonic cancer cells and the role of mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3-K) signalling were investigated. Methods: Three human colonic cancer cell lines (T
84 , HT29/CI.19A and Caco-2) were treated with leptin. Cell proliferation was measured using the XTT® colorimetric assay and apoptosis by a cell death enzyme-linked immunosorbent assay. Inhibitors of MAPK and PI3-K were used to evaluate the role of these signalling pathways. Phosphorylation of the downstream components extracellular signal-regulated kinase (ERK) 1/2 and Akt was detected by western blotting. Results: Leptin increased cell number in all cell lines in a dose-dependent manner and reduced the number of apoptotic cells in a cell line-dependent manner. Leptin also caused ERK1/2 and Akt phosphorylation. Pretreatment with inhibitors of MAPK and PI3-K inhibited these responses, attenuated the mitogenic action of leptin and abolished its antiapoptotic effects. Conclusion: Chronic increases in leptin concentration may enhance the growth of colonic cancers via MAPK and PI3-K pathways. These effects of leptin could provide a link between obesity and colonic cancer, and may represent a target for anticancer drug development. [ABSTRACT FROM AUTHOR]- Published
- 2007
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10. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors.
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Wasserman, L., Flatt, S.W., Natarajan, L., Laughlin, G., Matusalem, M., Faerber, S., Rock, C.L., Barrett-Connor, E., and Pierce, J.P.
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OBESITY ,BREAST cancer ,PHYSIOLOGY of women ,HUMAN body composition ,BODY weight ,PROGESTERONE receptors - Abstract
BACKGROUND:: Obesity in women has been associated with a variety of factors, including genetic predisposition, social class, early age at menarche, exercise, alcohol consumption and diet. Obesity is a risk factor for the occurrence and the recurrence of breast cancer in postmenopausal women, perhaps because of increased exposure to estrogen, insulin and insulin-like growth factors (IGFs). The progesterone receptor (PR) and the steroid hormone receptor coactivator pCIP/ACTR/AIB1/TRAM1/RAC3 (AIB1) are hypothesized to mediate signaling crosstalk between these hormonal pathways. Polymorphisms in both genes have been described and their association with breast cancer risk reported. If genetic factors contribute to obesity, and the PR and AIB1 genes influence estrogenic, insulin and IGF pathways, then genetic patterns resulting from PR and AIB1 polymorphisms may be associated with obesity in postmenopausal women. OBJECTIVE:: We compared the PR and AIB1 genotypes of postmenopausal women with breast cancer with demographic, disease-related, reproductive, lifestyle and dietary variables in terms of the strength of their relationship with obesity (BMI=30?kg/m
2 ). SUBJECTS:: A total of 301 postmenopausal women previously diagnosed with Stage I, II or IIIA breast cancer, who are enrolled in the Women's Healthy Eating and Living (WHEL) study (age: 34.5-70.8?y, BMI: 17.8-54.6?kg/m2 ). MEASUREMENTS:: The PR polymorphism PROGINS was identified by PCR. The length of the AIB1 polyglutamine repeat was determined by PCR and nondenaturing gel electrophoresis or DNA sequencing. BMI was obtained at the baseline clinic visit upon entry into the WHEL study. Information about date of diagnosis, stage of disease, tumor hormone receptor status and adjuvant treatment received were obtained from medical records. Reproductive, menstrual history, demographic, family history of cancer, smoking history and exercise frequency and intensity information were obtained from questionnaires. Dietary and alcohol intake data came from four 24-h telephone recalls of food intake obtained at the study entry. RESULTS:: The combined inheritance of PROGINS A1/A1 and AIB1 28/29, 28/30, 28/31, 29/29 or 29/30 (AIB1 LG) genotypes (adjusted odds ratio (OR)=2.22 (95% confidence interval 1.25-3.93)) and early age at menarche (<12?y) (adjusted OR=2.34 (1.12-4.86)) were each associated with the risk for obesity. Current use of tamoxifen (adjusted OR=0.49 (0.28-0.87)) and an alcohol intake =10?g/day (adjusted OR=0.28 (0.11-0.77)) were inversely associated with BMI =30?kg/m2 . CONCLUSION:: Early age at menarche and a PROGINS A1/A1+AIB1 LG genetic pattern had comparable levels of association with obesity in this cross-sectional sample of postmenopausal women with breast cancer. Since this was a cross-sectional rather than a case-control design, the association between PROGINS and AIB1 genotype and obesity found in this sample should be considered preliminary, and must be re-evaluated with a new and larger sample.International Journal of Obesity (2004) 28, 49-56. doi:10.1038/sj.ijo.0802481 Published online 14 October 2003 [ABSTRACT FROM AUTHOR]- Published
- 2004
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11. Cigarette smoking and increased central adiposity.
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Barrett-Connor, Elizabeth, Khaw, Kay-Tee, Barrett-Connor, E, and Khaw, K T
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SMOKING ,OBESITY - Abstract
Study Objective: To determine whether cigarette smoking is associated with central obesity in men and women.Design: A cross-sectional survey.Setting: A geographically defined population of older white adults.Participants: Men (836) and women (1112) ages 50 to 79.Interventions: None.Measurements and Main Results: Waist-hip circumference ratio and body mass index (weight in kg/height in m2) were measured in participants wearing light clothing without shoes. Past and current cigarette smoking habits were ascertained by a standard self-administered questionnaire. Cigarette smokers had higher waist-hip ratios than non-smokers. We observed a dose-response relation of increasing waist-hip ratio with increasing number of cigarettes smoked. Although smokers were leaner than nonsmokers, the increased waist-hip ratio in smokers was independent of body mass index and was consistent within body-mass index tertiles. The associations, seen in both sexes, were stronger in women.Conclusions: Cigarette smokers have more central obesity than nonsmokers. These results suggest that body fat distribution can be modified by behavioral factors such as smoking. [ABSTRACT FROM AUTHOR]- Published
- 1989
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12. Targeting the Enteroendocrine System for Treatment of Obesity
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Miedzybrodzka, Emily L., Gribble, Fiona M., Reimann, Frank, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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13. Physical Activity, Obesity and Weight Loss Maintenance
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Brandt, Claus, Pedersen, Bente Klarlund, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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14. Precision Medicine and Obesity
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Sacoto, Daniel, Hurtado, Maria Daniela, Acosta, Andres, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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15. NAFLD and NASH: The Metabolically Diseased Liver
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Armandi, Angelo, Schattenberg, Jörn M., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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16. The Enteroendocrine System in Obesity
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Miedzybrodzka, Emily L., Reimann, Frank, Gribble, Fiona M., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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17. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance
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Piquet, Megan, Martínez, M. Carmen, Romacho, Tania, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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18. Epidemiology of Obesity
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Sørensen, Thorkild I. A., Martinez, Andrea Rodriguez, Jørgensen, Terese Sara Høj, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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19. The Circadian Clock and Obesity
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Sebti, Yasmine, Hebras, Aurore, Pourcet, Benoit, Staels, Bart, Duez, Hélène, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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20. Insights from Studies of White Adipose Tissue Using Single-Cell Approaches
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Mejhert, Niklas, Rydén, Mikael, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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21. From Obesity to Diabetes: The Role of the Adipose Organ
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Colleluori, Georgia, Perugini, Jessica, Giordano, Antonio, Cinti, Saverio, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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22. Obesity, Senescence, and Senolytics
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Chaib, Selim, Tchkonia, Tamara, Kirkland, James L., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor
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- 2022
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23. Cellular and Molecular Mechanisms of Fat Taste Perception
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Hichami, Aziz, Khan, Amira Sayed, Khan, Naim Akhtar, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Palmer, R. Kyle, editor, and Servant, Guy, editor
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- 2022
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24. Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
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Scheja, Ludger, Heeren, Joerg, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, von Eckardstein, Arnold, editor, and Binder, Christoph J., editor
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- 2022
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25. Gastrointestinal Uses of Botulinum Toxin
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Cariati, Maria, Chiarello, Maria Michela, Cannistra’, Marco, Lerose, Maria Antonietta, Brisinda, Giuseppe, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Whitcup, Scott M., editor, and Hallett, Mark, editor
- Published
- 2021
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26. Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories
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Krekels, Elke H. J., Knibbe, Catherijne A. J., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Kiess, Wieland, editor, Schwab, Matthias, editor, and van den Anker, Johannes, editor
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- 2020
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27. Targeting Bile Acid-Activated Receptors in Bariatric Surgery
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Ding, Lili, Fang, Zhipeng, Liu, Yanjun, Zhang, Eryun, Huang, Tracy, Yang, Li, Wang, Zhengtao, Huang, Wendong, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Fiorucci, Stefano, editor, and Distrutti, Eleonora, editor
- Published
- 2019
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28. N/OFQ-NOP System in Food Intake
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Micioni Di Bonaventura, Maria Vittoria, Micioni Di Bonaventura, Emanuela, Cifani, Carlo, Polidori, Carlo, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Ko, Mei-Chuan, editor, and Caló, Girolamo, editor
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- 2019
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29. Translational Aspects of Brown Fat Activation by Food-Derived Stimulants
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Yoneshiro, Takeshi, Matsushita, Mami, Saito, Masayuki, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor
- Published
- 2019
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30. Adipogenesis in Primary Cell Culture
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Larsen, Therese Juhlin, Jespersen, Naja Zenius, Scheele, Camilla, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor
- Published
- 2019
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31. Regulatory Small and Long Noncoding RNAs in Brite/Brown Adipose Tissue
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Scheideler, Marcel, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor
- Published
- 2019
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32. Brown-Like Adipocyte Progenitors Derived from Human iPS Cells: A New Tool for Anti-obesity Drug Discovery and Cell-Based Therapy?
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Yao, Xi, Salingova, Barbara, Dani, Christian, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor
- Published
- 2019
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33. Incretins
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Wu, Tongzhi, Rayner, Christopher K., Horowitz, Michael, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor
- Published
- 2016
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34. Signalling Networks Governing Metabolic Inflammation
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Dali-Youcef, Nassim, Ricci, Romeo, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor
- Published
- 2016
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35. Current and Emerging Treatment Options in Diabetes Care
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Clemmensen, Christoffer, Müller, Timo D., Finan, Brian, Tschöp, Matthias H., DiMarchi, Richard, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor
- Published
- 2016
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36. Adipose Tissue Stem Cells
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Müller, Sebastian, Kulenkampff, Elisabeth, Wolfrum, Christian, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor
- Published
- 2016
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37. Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms
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Ben-Shmuel, Sarit, Rostoker, Ran, Scheinman, Eyal J., LeRoith, Derek, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor
- Published
- 2016
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38. Endocannabinoids and Metabolic Disorders
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Gatta-Cherifi, Blandine, Cota, Daniela, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Pertwee, Roger G., editor
- Published
- 2015
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39. Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers
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Savolainen, Markku J., Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Moore, Philip, Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, von Eckardstein, Arnold, editor, and Kardassis, Dimitris, editor
- Published
- 2015
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40. Neurotrophins and the Regulation of Energy Balance and Body Weight
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Rios, M., Rosenthal, W., Editor-in-chief, Barrett, James E., Series editor, Buckingham, Julia, Series editor, Flockerzi, Veit, Series editor, Geppetti, Pierangelo, Series editor, Michel, Martin C., Series editor, Moore, Philip, Series editor, Page, Clive P., Series editor, Lewin, Gary R., editor, and Carter, Bruce D., editor
- Published
- 2014
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41. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503
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Rosenzweig-Lipson, Sharon, Zhang, Jean, Mazandarani, Hossein, Harrison, Boyd L., Sabb, Annmarie, Sabalski, Joan, Stack, Gary, Welmaker, Greg, Barrett, James E., and Dunlop, John
- Subjects
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ARACHIDONIC acid , *INOSITOL phosphates , *VITAMIN B complex , *NUTRITION disorders , *BIOCHEMISTRY - Abstract
Abstract: WAY-161503 ((4aR)-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one), a 5-HT2B/C receptor agonist, was characterized in vitro using stable Chinese hamster ovary cell lines expressing each of the human 5-HT2 receptors and in vivo in animal models of obesity. WAY-161503 displaced both agonist ([125I]2,5-dimethoxy-4-iodoamphetamine (DOI)) and antagonist ([3H]mesulergine) radioligand binding to the human 5-HT2C receptor with derived Ki values of 3.3 ± 0.9 and 32 ± 6 nM, respectively. Relative to 5-HT2C receptor binding, WAY-161503 was approximately 6-fold less potent at human 5-HT2A receptors ([125I]DOI) with a derived Ki value of 18 nM and 20-fold less potent at human 5-HT2B receptors ([3H]5-HT) with a derived Ki value of 60 nM. In functional studies, WAY-161503 was a full agonist in stimulating 5-HT2C-receptor-coupled [3H]inositol phosphate (IP) formation and calcium mobilization with EC50 values of 8.5 nM and 0.8 nM, respectively. WAY-161503 was also a 5-HT2B agonist (EC50s of 6.9 and 1.8 nM for IP and calcium, respectively). In IP studies, WAY-161503 was a weak 5-HT2A partial agonist (EC50, 802 nM) yet potently stimulated calcium mobilization (EC50, 7 nM) in 5-HT2A receptor-expressing cells. Functionally, WAY-161503 also stimulated the phospholipase A2-coupled arachidonic acid release in 5-HT2C receptor expressing cells albeit with lower potency (EC50, 38 nM) and efficacy (Emax, 77%) compared with activation of the PLC pathway. In vivo, WAY-161503 produced dose-dependent decreases in 2-h food intake in 24 h fasted normal Sprague–Dawley rats, diet-induced obese mice, and obese Zuker rats with ED50 values of 1.9 mg/kg, 6.8 mg/kg, and 0.73 mg/kg, respectively. The reduction in food intake in normal Sprague–Dawley rats was reversed by administration of the 5-HT2C receptor antagonist SB-242084. Following chronic administration (10 days) in growing Sprague–Dawley rats, WAY-161503 decreased food intake and attenuated body weight gain. Finally, following chronic administration (15 days) of WAY-161503 to obese Zuker rats, the rats maintained a 30% decrease in food intake over the 15-day period combined with a 25 g decrease in body weight relative to vehicle-treated controls demonstrating a lack of tolerance to its anorectic effects. [Copyright &y& Elsevier]
- Published
- 2006
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