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In our work, the photonuclear production of 198,199Au isotopes for nuclear medicine purposes was studied, and a method for their recovery from irradiated mercury was developed. The yields of the corresponding nuclear reactions were determined, and a comparison of various methods of obtaining gold radioisotopes was provided. New sorbents based on benzo-15-crown-5, which selectively binds gold, were studied, and the optimal conditions for Au recovery with a high degree of purification from mercury were found. It was established that, for the fast and quantitative recovery of Au isotopes, it was necessary to add at least 0.1 mg of the carrier. As a result, the developed method can be regularly used to obtain 198,199Au for the research of radiopharmaceuticals based on them. [ABSTRACT FROM AUTHOR]

The possibility of production a medical radionuclide 177Lu by irradiating natHfO2 by bremsstrahlung photons up to 55 MeV was investigated. The yields of the main nuclear reactions were measured. A procedure for one-step separation of carrier free 177Lu via extraction chromatography on the LN resin sorbent (Triskem) was developed. The radiochemical yield was 98%, separation factor was higher than 105. Isomeric ratio 177mLu/177Lu was estimated. Simulation of 177Lu production in photonuclear reactions on 178Hf, 179Hf and natHf nuclei was performed. The possibility of production of medical quantities was discussed. [ABSTRACT FROM AUTHOR]

Nowadays, cobalt isotopes 55Co, 57Co, and 58mCo are considered to be promising radionuclides in nuclear medicine, with 55Co receiving the most attention as an isotope for diagnostics by positron emission tomography. One of the current research directions is dedicated to its production using electron accelerators (via photonuclear method). In our work, the yields of nuclear reactions occurring during the irradiation of natNi and 60Ni by bremsstrahlung photons with energy up to 55 MeV were determined. A method of fast and simple cobalt isotopes separation from irradiated targets using extraction chromatography was developed. [ABSTRACT FROM AUTHOR]