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Metallothioneins are a special group of low-molecular-weight proteins with metal-binding properties, which make them promising chelators for the development of targeted radiopharmaceuticals, as well as with technetium-99m. The aim of this work is to study the biodistribution of 99mTc-metallothionein conjugate (99mTc-MT) in intact mice in comparison with unbound technetium-99m (Na99mTcO4). Low uptake of 99mTc-MT in the thyroid gland (1.20 ± 0.30%/g versus 267.2 ± 59.0%/g for Na99mTcO4) demonstrates the high stability of 99mTc-MT in vivo. The 99mTc-MT complex is rapidly eliminated from the bloodstream through the kidneys and is characterized by a reduced uptake in most organs and tissues compared to Na99mTcO4. [ABSTRACT FROM AUTHOR]

One of the important problems of radiopharmaceutics is the development of new approaches for the creation of radiopharmaceuticals based on antibodies while maintaining their specificity and affinity for antigens. The metal-binding protein metallothionein is proposed as a chelator for the α-emitting 213Bi radionuclide. The results of studying the biodistribution of 213Bi–metallothionein (213Bi–MT), 213Bi–immunoglobulin (213Bi–IgG), and unconjugated 213Bi in the form of 213BiCl3 in intact mice are presented. [ABSTRACT FROM AUTHOR]