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Your search keyword '"Fra, Joaquin"' showing total 3 results
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3 results on '"Fra, Joaquin"'

1. Gemcitabine and vinorelbine (GV) versus cisplatin, gemcitabine and vinorelbine (CGV) as first-line treatment in advanced non small cell lung cancer: Results of a prospective randomized phase II study

Author

Esteban, Emilio, Fra, Joaquin, Fernández, Yolanda, Corral, Norberto, Vieitez, José M., Palacio, Isabel, de Sande, José L., Fernández, José L., Muñiz, Isabel, Villanueva, Noemi, Estrada, Enrique, Mareque, Beatriz, Uña, Esther, Buesa, José M., and Lacave, Angel J.

Published
2006
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3. Cisplatin plus gemcitabine with or without vinorelbine as induction chemotherapy prior to radical locoregional treatment for patients with stage III non-small-cell lung cancer (NSCLC): Results of a prospective randomized study

Author

Esteban, Emilio, de Sande, Jose-Luis, Villanueva, Noemi, Corral, Norberto, Muñiz, Isabel, Vieitez, a, Fra, Joaquin, Fernández, Yolanda, Estrada, Enrique, Fernandez, José-Luis, Luque, Maria, Jimenez, Paula, Mareque, Beatriz, Capellan, Marta, Buesa, a, and Lacave, Angel Jimenez

Subjects
*VINORELBINE, *CISPLATIN, *DRUG therapy, *RADIOTHERAPY, *SURGERY
Abstract

Summary: To evaluate possible improvement in objective response of adding vinorelbine (V) to the combination of cisplatin/gemcitabine (CG) in induction chemotherapy for stage III NSCLC, patients (n =154) aged ≤75 years, Karnofsky index ≥70%, were stratified by stage (IIIA versus IIIB) and randomly assigned to receive: C (50mg/m2 i.v.) plus G (1250mg/m2 i.v.) or CG plus V (25mg/m2 i.v.). All drugs were administered on days 1 and 8 of an every 3-week cycle. At conclusion, local treatment (LT) with surgery and/or radiotherapy was scheduled. The results indicated that, following a median of 3 cycles, the overall efficacy was 65% in the CG and 61% in the CGV group. Most patients in both groups received radiotherapy as part of their LT. Pathological complete response was confirmed by surgery in 18% in the CG and 25% in the CGV group. Median progression-free survival was 368 days in the CG and 322 days in the CGV group. There were no statistically significant differences in toxicities between groups. We conclude that the CG and CGV combinations had similar efficacy and moderate toxicity, without accruing to the triplet combination. [Copyright &y& Elsevier]

Published
2007
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