1. Metabolic tumour volume is prognostic in patients with non-small-cell lung cancer treated with stereotactic ablative radiotherapy.
- Author
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Dosani, M., Yang, R., McLay, M., Wilson, D., Liu, M., Yong-Hing, C. J., Hamm, J., Lund, C. R., Olson, R., and Schellenberg, D.
- Subjects
NON-small-cell lung carcinoma ,STEREOTACTIC radiotherapy ,AKAIKE information criterion ,POSITRON emission tomography ,TUMORS - Abstract
Introduction Stereotactic ablative radiotherapy (SABR) is a relatively new technique for the curative-intent treatment of patients with inoperable early-stage non-small-cell lung cancer (NSCLC). Previous studies have demonstrated a prognostic value for positron emission tomography–computed tomography (PET/CT) parameters, including maximal standardized uptake value (SUV
max ), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) in lung cancer patients. We aimed to determine which PET/CT parameter is most prognostic of local control (LC) and overall survival (OS) in patients treated with SABR for NSCLC. Methods We conducted a retrospective review of patients treated with SABR for stage I inoperable NSCLC at BC Cancer between 2009 and 2013. The Akaike information criterion was used to compare the prognostic value of the various PET/CT parameters. Results The study included 134 patients with a median age of 76 years. Median tumour diameter was 2.2 cm, gross tumour volume was 8.1 mL, SUVmax was 7.9, MTV was 2.4 mL, and TLG was 10.9 SUV•mL. The 2-year LC was 92%, and OS was 66%. On univariate and multivariate analysis, imaging variables including tumour size, gross tumour volume, SUVmax , MTV, and TLG were all associated with worse LC. Tumour size was not associated with significantly worse OS, but other imaging variables were. The PET/CT parameter most prognostic of LC was MTV. Compared with SUVmax , TLG and MTV were more prognostic of OS. Conclusions In patients with early-stage NSCLC treated with SABR, MTV appears to be prognostic of LC and OS. [ABSTRACT FROM AUTHOR]- Published
- 2019
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