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Your search keyword '"Fidler JM"' showing total 5 results
Start Over Author "Fidler JM" Topic nitrophenols
5 results on '"Fidler JM"'

1. In vivo immune response to TNP hapten coupled to thymus-independent carrier lipopolysaccharide.

Author

Fidler JM

Subjects
Animals, Antibody Specificity, Antibody-Producing Cells, Erythrocytes immunology, Escherichia coli immunology, Female, Haptens, Hemolytic Plaque Technique, Horses immunology, Immunity, Maternally-Acquired, Immunologic Memory, Lymphocytes immunology, Lysine, Male, Mice, Polysaccharides, Bacterial, Radiation Chimera, Sheep immunology, Spleen cytology, Thymus Gland abnormalities, Antibody Formation, Lipopolysaccharides immunology, Nitrophenols immunology
Published
1975
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2. Antigen-inhibited B-lymphocyte differentiation. X. Sedimentation velocity characterization of antigen-binding cells and antibody-forming-cell progenitors in the in vitro microculture immune response of unprimed CBA mice to NIP--POL antigen.

Author

Fidler JM and Pike BL

Subjects
Animals, Animals, Newborn, Cell Differentiation, Cell Separation, Germ-Free Life, Immunoglobulin M, Mice, Mice, Inbred CBA, Spleen immunology, Antibody-Producing Cells immunology, Antigens, B-Lymphocytes cytology, Bacterial Proteins immunology, Binding Sites, Antibody, Flagellin immunology, Nitrohydroxyiodophenylacetate immunology, Nitrophenols immunology
Published
1977
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3. Immunologic tolerance to a hapten. 3. Induction of tolerance to trinitrophenyl in B cells in various differentiation states.

Author

Fidler JM and Golub ES

Subjects
Animals, Antigens, Antilymphocyte Serum, Cell Differentiation, Cells, Cultured, Erythrocytes immunology, Female, Fetus, Hemolytic Plaque Technique, Horses immunology, Immunization, Passive, Liver cytology, Lymphocyte Activation, Lymphocyte Depletion, Mice, Radiation Chimera, Sheep immunology, Spleen cytology, Sulfonic Acids, T-Lymphocytes immunology, Thymectomy, B-Lymphocytes immunology, Haptens, Immune Tolerance, Nitrophenols
Published
1974

4. Induction of tolerance to a hapten. II. Maintenance and escape of the tolerant state to TNP.

Author

Fidler JM and Golub ES

Subjects
Animals, Antibodies, Anti-Idiotypic, Antibody-Producing Cells, Dose-Response Relationship, Drug, Immunoglobulin M, Injections, Mercaptoethanol pharmacology, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Viral Plaque Assay, Antibody Formation, Haptens, Immune Tolerance drug effects, Nitrobenzenes pharmacology, Nitrophenols pharmacology, Sulfonic Acids pharmacology
Published
1973

5. Immunological tolerance to a hapten. I. Induction and maintenance of tolerance to trinitrophenyl with trinitrobenzene sulfonic acid.

Author

Fidler JM and Golub ES

Subjects
Animals, Antibody-Producing Cells, Antigen-Antibody Reactions, Drug Tolerance drug effects, Erythrocytes immunology, Hemolytic Plaque Technique, Horses immunology, Immunization, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Nitrobenzenes administration & dosage, Sheep immunology, Sulfonic Acids, Thymus Gland immunology, Time Factors, gamma-Globulins, Immune Tolerance drug effects, Nitrobenzenes pharmacology, Nitrophenols
Abstract

Treatment of mice with a nonimmunogenic preparation of free reactive hapten, trinitrobenzene sulfonic acid (TNBS), leads to the induction of a state of tolerance to the hapten, 2,4,6-trinitrophenyl (TNP). This is determined by the lack of response to the haptenic moiety in an immunogenic hapten-carrier conjugate (TNP-SRBC) as assayed both by serum antibody titrations and the hemolytic plaque assay. The tolerance produced is specific for the hapten, since the anticarrier responses are essentially unaltered compared with the control values. The unresponsiveness induced by TNBS treatment is a dose-dependent phenomenon, becoming less complete at lower doses of TNBS. The tolerance is of a definite length, both in its induction phase and in the duration of the established unresponsive state. Tolerance can be maintained and extended, and may also be reentered once escape has been initiated.

Published
1973
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