1. Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs.
- Author
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López GV, Batthyány C, Blanco F, Botti H, Trostchansky A, Migliaro E, Radi R, González M, Cerecetto H, and Rubbo H
- Subjects
- Animals, Antioxidants chemical synthesis, Antioxidants chemistry, Antioxidants pharmacology, Humans, In Vitro Techniques, Magnetic Resonance Spectroscopy, Nitric Oxide Donors chemistry, Rats, Rats, Wistar, Spectrophotometry, Infrared, Tocopherols chemistry, Vasodilator Agents chemical synthesis, Vasodilator Agents chemistry, Vasodilator Agents pharmacology, Atherosclerosis prevention & control, Nitric Oxide chemistry, Nitric Oxide Donors chemical synthesis, Nitric Oxide Donors pharmacology, Tocopherols chemical synthesis, Tocopherols pharmacology
- Abstract
Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.
- Published
- 2005
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