Author: "Che, Haiyan" / Topic: nitric oxide - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Che, Haiyan" Topic nitric oxide

Author: Pham TA, Che H, Phan PT, Lee JW, Kim SS, and Park H
Subjects: Acetophenones chemistry, Aldehydes chemistry, Animals, Anti-Anxiety Agents pharmacology, Cell Line, Transformed, Flavanones pharmacology, Flavonoids pharmacology, Lipopolysaccharides pharmacology, Macrophages cytology, Macrophages drug effects, Mice, Microglia cytology, Microglia drug effects, Nitric Oxide biosynthesis, Nitric Oxide Synthase Type II metabolism, Nitrophenols chemistry, Anti-Anxiety Agents chemical synthesis, Flavonoids chemical synthesis, Nitric Oxide antagonists & inhibitors, Nitric Oxide Synthase Type II antagonists & inhibitors
Abstract: A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 μM) than that of wogonin (IC(50)=7.80 μM)., (Copyright © 2012. Published by Elsevier Ltd.)
Published: 2012
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Author: Che H, Lim H, Kim HP, and Park H
Subjects: Animals, Catalysis, Cell Line, Flavonoids chemistry, Lipopolysaccharides pharmacology, Macrophages drug effects, Macrophages metabolism, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Nitric Oxide biosynthesis, Dinoprostone antagonists & inhibitors, Flavonoids pharmacology, Nitric Oxide antagonists & inhibitors
Abstract: A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction of 8-iodo-5,7-dimethoxyflavone and alkyl/areneboronic acids as a key reaction. Among the analogs tested, 5,7-dihydroxy-8-(pyridine-4-yl)flavone (3d) showed strong biological activities against COX-2 catalyzed PGE(2) and iNOS-mediated NO production from LPS-induced RAW 264.7 cells compared to those of chrysin., (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)
Published: 2011
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Author: Che, Haiyan, Park, Byung Kyu, Lim, Hyun, Kim, Hyun Pyo, Chang, Hyeun Wook, Jeong, Jin-Hyun, and Park, Haeil
Subjects: *ORGANIC synthesis, *CYCLOOXYGENASE 2 inhibitors, *NITRIC oxide, *ENZYME inhibitors, *ANTI-inflammatory agents, *CELL lines
Abstract: Abstract: In order to establish anti-inflammatory potential of biflavonoids, 17 biflavone derivatives having a 6-O-7″ linkage were synthesized and their effects on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were evaluated. The basic molecule (6-O-7″ biflavone) potently inhibited COX-2-mediated PGE2 production (IC50: <2μM), being less active on iNOS-mediated NO production (IC50: >50μM) from lipopolysaccharide-treated RAW 264.7 cells, a mouse macrophage cell line. Generally, the hydroxyl/methoxyl substitution(s) on the basic biflavone (6-O-7″) reduced the inhibitory activity of PGE2 production, while the effects on NO production were varied. It is suggested that the basic biflavone (6-O-7″) may have a potential for new anti-inflammatory agent. [Copyright &y& Elsevier]
Published: 2009
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