1. Biodegradable therapeutic MOFs for the delivery of bioactive molecules.
- Author
-
Miller SR, Heurtaux D, Baati T, Horcajada P, Grenèche JM, and Serre C
- Subjects
- Crystallography, X-Ray, Ferric Compounds chemistry, Models, Molecular, Temperature, Drug Delivery Systems, Ferric Compounds metabolism, Ferric Compounds therapeutic use, Iron chemistry, Niacin chemistry
- Abstract
A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.
- Published
- 2010
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