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Start Over Author "Belsky YP" Topic nf-kappa b
2 results on '"Belsky YP"'

1. Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response.

Author

Ligacheva AA, Ivanova AN, Belsky YP, Belska NV, Trofimova ES, Danilets MG, and Dygai AM

Subjects
Analysis of Variance, Animals, Cytokines immunology, Diclofenac pharmacology, Diclofenac therapeutic use, Erythrocytes, Female, Gold Sodium Thiomalate therapeutic use, Hypersensitivity, Delayed chemically induced, Hypersensitivity, Immediate chemically induced, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Ovalbumin toxicity, Gold Sodium Thiomalate pharmacology, Hypersensitivity, Delayed drug therapy, Hypersensitivity, Immediate drug therapy, Immunity, Cellular immunology, NF-kappa B antagonists & inhibitors, Th1 Cells immunology, Th2 Cells immunology
Abstract

We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.

Published
2012
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2. Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-κB.

Author

Belsky YP, Ivanova AN, Danilets MG, Belska NV, Ligatcheva AA, Uchasova EG, and Reikhart DV

Subjects
Animals, Anti-Inflammatory Agents therapeutic use, Diclofenac pharmacology, Diclofenac therapeutic use, Female, Gold Sodium Thiomalate therapeutic use, Inflammation chemically induced, Inflammation pathology, Macrophages, Peritoneal drug effects, Macrophages, Peritoneal metabolism, Male, Mice, Mice, Inbred C57BL, Nitric Oxide metabolism, Anti-Inflammatory Agents pharmacology, Gold Sodium Thiomalate pharmacology, Inflammation drug therapy, NF-kappa B antagonists & inhibitors
Abstract

We compared the effects of NF-κB inhibitor aurothiomalate and voltaren on NO production by mouse macrophages in vitro, their ability to cause local edema at the site of injection, and their effect on carrageenan-induced inflammation. High concentrations of aurothiomalate reduced NO production, while in low concentrations both aurothiomalate and voltaren stimulated this process. When injected into mouse footpad, aurothiomalate in a dose >1 mM and voltaren in a dose >1.6 μM induce paw edema. Both compounds suppressed carrageenan-induced inflammation, but the efficacy of aurothiomalate 2-fold exceeded that of voltaren.

Published
2011
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