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8 results on '"Lalumera M"'

1. [The production of superoxide anion (O2-) by polymorphonuclear cells in patients with rheumatoid arthritis].

Author

Lalumera M, Berti C, Pellegrini R, Morozzi G, and Marcolongo R

Subjects
Adult, Aged, Herpesvirus 4, Human metabolism, Humans, Middle Aged, Mycoplasma metabolism, Rheumatoid Factor pharmacology, Synovial Fluid metabolism, Synovial Membrane metabolism, Zymosan pharmacology, Arthritis, Rheumatoid blood, Neutrophils metabolism, Oxygen blood, Superoxides blood
Abstract

Superoxide anion production has been determined in controls and RA patients PMNs stimulated with zymosan, rheumatoid synovial membrane, nodule and synovial fluid, rheumatoid factor, aggregated gamma-globulins, Mycoplasma and Epstein-Barr virus. Patients with RA showed an increased production of O2- after incubation with zymosan and rheumatoid tissue extracts or synovial fluid in comparison to normal controls. The findings indicate that rheumatoid PMNs become activated by different stimuli to produce an excess of O2- which can contribute to chronic inflammatory process.

Published
1982

2. [In vitro effects of non-steroidal anti-inflammatory drugs on production of oxygen radicals evaluated by the chemiluminescent response of polymorphonuclear leukocytes].

Author

Mazzullo G, Calabria AA, Lalumera M, Fioravanti A, Bacarelli MR, Pucci G, and Renieri A

Subjects
Arthritis, Rheumatoid pathology, Aspirin pharmacology, Cell Membrane drug effects, Diclofenac pharmacology, Free Radicals, Humans, Indomethacin pharmacology, Luminescent Measurements, Neutrophils drug effects, Piroxicam, Thiazines pharmacology, Zymosan pharmacology, Anti-Inflammatory Agents pharmacology, Neutrophils metabolism, Oxygen metabolism
Published
1985

4. [In vitro study on the possible inflammatory mechanism of ferrous ions: effect on the production of oxygen free radicals].

Author

Calabria AA, Lalumera M, Mazzullo G, Giordano N, Cavallo G, Morozzi G, and Marcolongo R

Subjects
Arthritis, Rheumatoid pathology, Deferoxamine pharmacology, Humans, Hydroxides, Hydroxyl Radical, In Vitro Techniques, Luminescent Measurements, Zymosan pharmacology, Ferric Compounds pharmacology, Ferrous Compounds pharmacology, Iron pharmacology, Neutrophils drug effects, Oxygen metabolism
Published
1985

5. [Effect of inflammation mediators and antirheumatic drugs on the production of superoxide anion (O2-) by polymorphonuclear cells in normals and rheumatoid arthritis].

Author

Pellegrini R, Lalumera M, Berti C, Morozzi G, and Marcolongo R

Subjects
Adrenal Cortex Hormones pharmacology, Alprostadil, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Cyclic AMP pharmacology, Cyclic GMP pharmacology, Humans, Neutrophils drug effects, Prostaglandins E pharmacology, Theophylline pharmacology, Arthritis, Rheumatoid blood, Neutrophils metabolism, Oxygen blood, Superoxides blood
Published
1982

6. In vitro and ex vivo effects of different corticosteroids on polymorphonuclear leukocyte functions.

Author

Marcolongo R, Lalumera M, Calabria A, and Imbimbo B

Subjects
Adult, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid physiopathology, Cells, Cultured, Chemotaxis, Leukocyte drug effects, Dose-Response Relationship, Drug, Female, Humans, Kinetics, Luminescent Measurements, Middle Aged, Neutrophils physiology, Superoxides metabolism, Zymosan pharmacology, Betamethasone pharmacology, Methylprednisolone pharmacology, Neutrophils drug effects, Pregnenediones pharmacology
Published
1984

8. The 'switch-off' mechanism of spontaneous resolution of acute gout attack

Author

Marcolongo R, Aa, Calabria, Lalumera M, Gerli R, Alessandrini C, and Cavallo G

Subjects
Inflammation, Gout, Neutrophils, Remission, Spontaneous, Calorimetry, Uric Acid, Kinetics, Durapatite, Superoxides, Acute Disease, Luminescent Measurements, Microscopy, Electron, Scanning, Urea, Humans, Hydroxyapatites, Lymphocytes, Allantoin, Acute-Phase Reaction, Crystallization
Abstract

Urate crystal size change and the modification of coated proteins by oxygen radicals released by stimulated polymorphonuclear cells (PMN) could represent a likely "switch-off" mechanism of the spontaneous resolution of acute gout attack. The absorption spectra and the uric acid, allantoin and urea concentrations were determined before and after in vitro exposition of monosodium urate (MSU) crystals to superoxide anion (O2) photochemically generated. The results showed a complete dissolution of MSU crystals after incubation under O2-, with decrease of uric acid and increase of allantoin and urea concentrations. Our results were confirmed by polarizing, electron microscopy and calorimetric techniques. The results obtained seem to confirm that the spontaneous resolution of acute gout attack could be attributed to the dissolving effect on urate crystals and the modification of coated proteins by O2- released by phagocytizing PMN.

Published
1988

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