1. Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies.
- Author
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Gramatges MM, Fani P, Nadeau K, Pereira S, and Jeng MR
- Subjects
- Adult, Antibodies, Antineutrophil Cytoplasmic immunology, Female, Humans, Infant, Newborn, Male, Pregnancy, HLA Antigens immunology, Isoantibodies immunology, Maternal-Fetal Exchange immunology, Neutropenia congenital, Neutropenia immunology, Thrombocytopenia, Neonatal Alloimmune immunology
- Abstract
Neonatal thrombocytopenia or neutropenia may result from passive transfusion of maternally derived antibodies. Antibodies against platelet antigens are commonly associated with neonatal alloimmune thrombocytopenia (NAIT), and anti-neutrophil antibodies are frequently identified in alloimmune neonatal neutropenia (ANN). Combined alloimmune cytopenias in the newborn are rarely reported; even fewer reports document human leukocyte antigen (HLA) antibodies as a potential cause of neonatal thrombocytopenia or neutropenia. We describe neutropenia and thrombocytopenia in a newborn associated with markedly elevated maternal HLA antibodies in the absence of anti-neutrophil or anti-platelet antibodies to highlight consideration of HLA antibodies in the pathogenesis of ANN and NAIT., (Copyright 2009 Wiley-Liss, Inc.)
- Published
- 2009
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