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Applying TQRPA calculations of Gamow–Teller strength functions in hot nuclei, we compute the (anti)neutrino spectra and energy loss rates arising from weak processes on hot 56 Fe under pre-supernova conditions. We use a realistic pre-supernova model calculated by the stellar evolution code MESA. Taking into account both charged and neutral current processes, we demonstrate that weak reactions with hot nuclei can produce high-energy (anti)neutrinos. We also show that, for hot nuclei, the energy loss via (anti)neutrino emission is significantly larger than that for nuclei in their ground state. It is found that the neutral current de-excitation via the ν ν ¯ -pair emission is presumably a dominant source of antineutrinos. In accordance with other studies, we confirm that the so-called single-state approximation for neutrino spectra might fail under certain pre-supernova conditions. [ABSTRACT FROM AUTHOR]