1. Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders
- Author
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Andrea Mastinu, Giulia Ferrari-Toninelli, Maurizio Memo, and Sara Anna Bonini
- Subjects
0301 basic medicine ,Microtubule dynamics ,microtubule stabilizing agents ,Neurogenesis ,Synaptogenesis ,Review ,Biology ,Brain malformation ,Microtubule ,Microtubule stabilizing agents ,Neurodevelopmental disorders ,Catalysis ,Molecular Biology ,Computer Science Applications1707 Computer Vision and Pattern Recognition ,Spectroscopy ,Physical and Theoretical Chemistry ,Organic Chemistry ,Inorganic Chemistry ,Microtubules ,lcsh:Chemistry ,03 medical and health sciences ,Cortical abnormalities ,Cell Movement ,Humans ,lcsh:QH301-705.5 ,Cell Proliferation ,Neurons ,neurodevelopmental disorders ,brain malformation ,Brain ,Cell Differentiation ,General Medicine ,Computer Science Applications ,Cell biology ,Corticogenesis ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Stabilizing Agents ,Microtubule-Associated Proteins ,microtubule - Abstract
Neurodevelopmental disorders (NDDs) are characterized by neuroanatomical abnormalities indicative of corticogenesis disturbances. At the basis of NDDs cortical abnormalities, the principal developmental processes involved are cellular proliferation, migration and differentiation. NDDs are also considered “synaptic disorders” since accumulating evidence suggests that NDDs are developmental brain misconnection syndromes characterized by altered connectivity in local circuits and between brain regions. Microtubules and microtubule-associated proteins play a fundamental role in the regulation of basic neurodevelopmental processes, such as neuronal polarization and migration, neuronal branching and synaptogenesis. Here, the role of microtubule dynamics will be elucidated in regulating several neurodevelopmental steps. Furthermore, the correlation between abnormalities in microtubule dynamics and some NDDs will be described. Finally, we will discuss the potential use of microtubule stabilizing agents as a new pharmacological intervention for NDDs treatment.
- Published
- 2017