1. Psychiatric co-morbidity is highly prevalent in idiopathic cervical dystonia and significantly influences health-related quality of life: Results of a controlled study
- Author
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Marina A. J. Tijssen, Anouk Kuiper, G. Douma, Marenka Smit, M.E. Pouwels, Anna L. Bartels, Vladimir Han, H.J.G. Dieks, J.M.T.H. Oen, V.C.R. Jiawan, B. van Harten, and Movement Disorder (MD)
- Subjects
Adult ,Male ,medicine.medical_specialty ,DISORDERS ,Health-related quality of life ,INVENTORY ,Severity of Illness Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Severity of illness ,Prevalence ,medicine ,Humans ,ANXIETY ,Cervical dystonia ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Dystonia ,FOCAL DYSTONIA ,Psychiatric assessment ,Middle Aged ,Focal dystonia ,medicine.disease ,DEPRESSION ,Anxiety Disorders ,Comorbidity ,030227 psychiatry ,PSYCHOMETRIC PROPERTIES ,Neurology ,Dystonic Disorders ,Quality of Life ,Non-motor ,Anxiety ,Female ,Neurology (clinical) ,SPASMODIC TORTICOLLIS ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,COMORBIDITY ,030217 neurology & neurosurgery - Abstract
Introduction: The aim of this study was to systematically investigate the prevalence of psychiatric disorders and factors influencing health-related quality of life (HR-QoL) in cervical dystonia (CD) patients, in the context of objective dystonia motor severity.Methods: We studied 50 CD patients and 50 matched healthy controls. Psychiatric assessment included the MINI PLUS interview and quantitative questionnaires. Dystonia motor severity (based on video evaluation), pain and disability were determined with the TWSTRS rating scale. In addition, severity of tremor and jerks was evaluated with the 7-point CGI-S scale. HR-QoL was determined with the RAND-36 item Health Survey and predictors of HR-QoL were assessed using multiple regression analysis.Results: In CD patients, the MINI-PLUS revealed a significantly higher prevalence of psychiatric disorders (64% vs. 28%, p = 0.001), with substantially more depression (32% vs. 14%) and anxiety disorders (42% vs. 8%). This was confirmed by the quantitative rating scales. Disease characteristics did not differ between patients with and without a psychiatric diagnosis. HR-QoL in dystonia patients was significantly lowered. The most important predictors of HR-QoL appeared severity of depressive symptoms, pain and disability, but not severity of motor symptoms.Conclusion: Psychiatric co-morbidity is highly prevalent and is an important predictor of HR-QoL in CD patients, rather than dystonia motor severity. Our findings support the theory of a shared neurobiology for motor and non-motor features and highlight the need for systematic research into psychiatric disorders in dystonia. Adequate treatment of psychiatric symptoms could significantly contribute to better overall quality of life of CD patients. (C) 2016 Elsevier Ltd. All rights reserved.
- Published
- 2016