1. Spatiotemporal structure of cell fate decisions in murine neural crest.
- Author
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Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, and Adameyko I
- Subjects
- Animals, Basic Helix-Loop-Helix Transcription Factors metabolism, Cell Lineage, Mesenchymal Stem Cells metabolism, Mice, Mice, Mutant Strains, Nerve Tissue Proteins metabolism, Neural Crest metabolism, Neural Stem Cells metabolism, Neural Tube cytology, Neural Tube embryology, Neuroglia cytology, Neurons cytology, Nuclear Proteins metabolism, Single-Cell Analysis, Twist-Related Protein 1 metabolism, Gene Expression Regulation, Developmental, Mesenchymal Stem Cells cytology, Neural Crest cytology, Neural Crest embryology, Neural Stem Cells cytology, Neurogenesis genetics
- Abstract
Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Published
- 2019
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