8 results on '"PRIDE, NATALIE A"'
Search Results
2. Delineating the autistic phenotype in children with neurofibromatosis type 1
- Author
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Chisholm, Anita K., Haebich, Kristina M., Pride, Natalie A., Walsh, Karin S., Lami, Francesca, Ure, Alex, Maloof, Tiba, Brignell, Amanda, Rouel, Melissa, Granader, Yael, Maier, Alice, Barton, Belinda, Darke, Hayley, Dabscheck, Gabriel, Anderson, Vicki A., Williams, Katrina, North, Kathryn N., and Payne, Jonathan M.
- Published
- 2022
- Full Text
- View/download PDF
3. Neuropsychological factors associated with performance on the rey-osterrieth complex figure test in children with neurofibromatosis type 1.
- Author
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Maier, Alice, Pride, Natalie A., Hearps, Stephen J. C., Shah, Nijashree, Porter, Melanie, North, Kathryn N., and Payne, Jonathan M.
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NEUROFIBROMATOSIS 1 , *WECHSLER Intelligence Scale for Children , *AGE , *EXECUTIVE function , *PERFORMANCE in children , *CHILDREN with dyslexia - Abstract
Children with neurofibromatosis type 1 (NF1) are at considerable risk for cognitive difficulties, including visuospatial deficits and executive dysfunction. This study aimed to (1) assess the overall performance of children with NF1 on the Rey-Osterrieth Complex Figure Test (RCFT) compared to unaffected siblings and (2) examine neuropsychological predictors of RCFT performance in children with NF1. A retrospective clinical audit was performed on neuropsychological records from a multidisciplinary NF1 Clinic in Australia. We searched for children that had completed an assessment between 2000 and 2015 which included the RCFT and other neuropsychological outcomes in this study. These included the Wechsler Intelligence Scale for Children, Judgment of Line Orientation (JLO), Tower of London test, Conners ADHD Scales, and the Behavioral Rating Inventory of Executive Function (BRIEF). The study population consisted of 191 children with NF1 aged 6–16 years, and 55 unaffected siblings recruited from a separate study. Results revealed that 62% of children with NF1 performed at or below the first percentile on the RCFT copy, which was significantly worse than their unaffected siblings. Visuospatial skills, parent-rated executive abilities, ADHD symptoms, and intellectual skills all predicted poorer performance on the RCFT copy, however the best fitting multiple regression model only contained the JLO, BRIEF Metacognition Index, and chronological age. The JLO emerged as the strongest predictor of RCFT performance. This study provides evidence that visuospatial deficits are a key driver of reduced RCFT performance in NF1 and that executive skills as well as a younger age are also independent predictors of RCFT performance. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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4. Social Function and Autism Spectrum Disorder in Children and Adults with Neurofibromatosis Type 1: a Systematic Review and Meta-Analysis
- Author
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Chisholm, Anita K., Anderson, Vicki A., Pride, Natalie A., Malarbi, Stephanie, North, Kathryn N., and Payne, Jonathan M.
- Published
- 2018
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5. Sensory Processing in Children and Adolescents with Neurofibromatosis Type 1.
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Pride, Natalie A., Haebich, Kristina M., Walsh, Karin S., Lami, Francesca, Rouel, Melissa, Maier, Alice, Chisholm, Anita K., Lorenzo, Jennifer, Hearps, Stephen J. C., North, Kathryn N., and Payne, Jonathan M.
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SENSES , *CAREGIVERS , *SENSORY disorders , *CHILDREN'S hospitals , *CROSS-sectional method , *RISK assessment , *SENSORY stimulation , *COMPARATIVE studies , *ATTENTION-deficit hyperactivity disorder , *RESEARCH funding , *DESCRIPTIVE statistics , *AUTISM , *AFFECTIVE disorders , *NEUROFIBROMATOSIS 1 , *PSYCHOLOGICAL adaptation , *SOCIAL skills , *ANXIETY , *DISEASE risk factors , *DISEASE complications , *CHILDREN , *ADOLESCENCE - Abstract
Simple Summary: Difficulties in sensory processing are often found in neurodevelopmental disorders and can significantly impact how a child responds to and functions within their environment. Studies examining sensory processing in children with neurofibromatosis type 1 (NF1) are sparse. This cross-sectional study aims to address this gap by examining parent-reported sensory processing in a sample of 152 children with NF1. Approximately 61% of children with NF1 displayed differences in how they respond to sensory stimuli when compared to a typically developing control group. These difficulties were seen equally across ages and sex and were found to be associated with a higher degree of autistic behaviors, ADHD symptoms, lower adaptive skills, poorer social skills, and increased anxiety and affective symptoms. The results highlight the importance of accommodating multisensory processing difficulties at home and school when deciding how to support a child with NF1 across environments. Despite the evidence of elevated autistic behaviors and co-occurring neurodevelopmental difficulties in many children with neurofibromatosis type 1 (NF1), we have a limited understanding of the sensory processing challenges that may occur with the condition. This study examined the sensory profile of children and adolescents with NF1 and investigated the relationships between the sensory profiles and patient characteristics and neuropsychological functioning. The parent/caregivers of 152 children with NF1 and 96 typically developing children completed the Sensory Profile 2 (SP2), along with standardized questionnaires assessing autistic behaviors, ADHD symptoms, internalizing symptoms, adaptive functioning, and social skills. Intellectual functioning was also assessed. The SP2 data indicated elevated sensory processing problems in children with NF1 compared to typically developing children. Over 40% of children with NF1 displayed differences in sensory registration (missing sensory input) and were unusually sensitive to and unusually avoidant of sensory stimuli. Sixty percent of children with NF1 displayed difficulties in one or more sensory modalities. Elevated autistic behaviors and ADHD symptoms were associated with more severe sensory processing difficulties. This first detailed assessment of sensory processing, alongside other clinical features, in a relatively large cohort of children and adolescents with NF1 demonstrates the relationships between sensory processing differences and adaptive skills and behavior, as well as psychological well-being. Our characterization of the sensory profile within a genetic syndrome may help facilitate more targeted interventions to support overall functioning. [ABSTRACT FROM AUTHOR]
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- 2023
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6. The mediating role of ADHD symptoms between executive function and social skills in children with neurofibromatosis type 1.
- Author
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Haebich, Kristina M., Dao, Duy P., Pride, Natalie A., Barton, Belinda, Walsh, Karin S., Maier, Alice, Chisholm, Anita K., Darke, Hayley, Catroppa, Cathy, Malarbi, Stephanie, Wilkinson, Jake C., Anderson, Vicki A., North, Kathryn N., and Payne, Jonathan M.
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EXECUTIVE function ,SOCIAL skills ,TIC disorders ,ATTENTION-deficit hyperactivity disorder ,NEUROFIBROMATOSIS 1 ,SYMPTOMS ,CHILD psychology ,BILINGUALISM - Abstract
Children with neurofibromatosis type 1 (NF1) often experience executive dysfunction, attention deficit/hyperactivity disorder (ADHD) symptoms and poor social skills, however, the nature of the relationships between these domains in children with NF1 is unclear. This study investigated these relationships using primary caregiver ratings of executive functions, ADHD symptoms and social skills in children with NF1. Participants were 136 children with NF1 and 93 typically developing (TD) controls aged 3–15 years recruited from 3 multidisciplinary neurofibromatosis clinics in Melbourne and Sydney, Australia, and Washington DC, USA. Mediation analysis was performed on primary outcome variables: parent ratings of executive functions (Behavior Rating Inventory of Executive Function, Metacognition Index), ADHD symptoms (Conners-3/Conners ADHD Diagnostic and Statistical Manual for Mental Disorders Scales) and social skills (Social Skills Improvement System-Rating Scale), adjusting for potential confounders (full scale IQ, sex, and social risk). Results revealed significantly poorer executive functions, elevated ADHD symptoms and reduced social skills in children with NF1 compared to controls. Poorer executive functions significantly predicted elevated ADHD symptoms and poorer social skills. Elevated ADHD symptoms significantly mediated the relationship between executive functions and social skills problems although did not fully account for social dysfunction. This study provides evidence for the importance of targeting ADHD symptoms as part of future interventions aimed at promoting prosocial behaviors in children with NF1. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1.
- Author
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Payne, Jonathan M., Haebich, Kristina M., MacKenzie, Rachel, Walsh, Karin S., Hearps, Stephen J. C., Coghill, David, Barton, Belinda, Pride, Natalie A., Ullrich, Nicole J., Tonsgard, James H., Viskochil, David, Schorry, Elizabeth K., Klesse, Laura, Fisher, Michael J., Gutmann, David H., Rosser, Tena, Packer, Roger J., Korf, Bruce, Acosta, Maria T., and Bellgrove, Mark A.
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ATTENTION-deficit hyperactivity disorder ,NEUROFIBROMATOSIS 1 ,NEUROPSYCHOLOGICAL tests ,COGNITION ,QUALITY of life ,EXECUTIVE function - Abstract
Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. Social functioning in adults with neurofibromatosis type 1.
- Author
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Pride, Natalie A., Crawford, Hilda, Payne, Jonathan. M., and North, Kathryn N.
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NEUROFIBROMATOSIS 1 , *DELINQUENT behavior , *GENDER differences (Psychology) , *SOCIAL skills , *EXECUTIVE function - Abstract
Highlights: [•] Adults with NF1 have poorer social skills than unaffected adults. [•] Social skills deficits are more prominent in males with NF1 than females. [•] Nearly 50% of adults with NF1 are rated with impaired social skills. [•] A deficit in prosocial behaviours rather, than antisocial behaviours is evident in NF1. [•] A link between executive functions, social processing and social skills exists in NF1. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
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