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Spinal cord injury (SCI) is a debilitating condition that can significantly affect an individual's life, causing paralysis, autonomic dysreflexia, and chronic pain. Transspinal stimulation (TSS) is a non-invasive form of neuromodulation that activates the underlying neural circuitries of the spinal cord. Application of TSS can be performed through multiple stimulation protocols, which may vary in the electrodes' size or position as well as stimulation parameters, and which may influence the response of motor functions to the stimulation. Due to the novelty of TSS, it is beneficial to summarize the available evidence to identify the range of parameters that may provide the best outcomes for motor response. The PubMed and Google Scholar databases were searched for studies examining the effects of TSS on limb motor function. A literature search yielded 34 studies for analysis, in which electrode placement and stimulation parameters varied considerably. The stimulation protocols from each study and their impact on limb motor function were summarized. Electrode placement was variable based on the targeted limb. Studies for the upper limbs targeted the cervical enlargement with anatomical placement of the cathode over the cervical vertebral region. In lower-limb studies, the cathode(s) were placed over the thoracic and lumbar vertebral regions, to target the lumbar enlargement. The effects of carrier frequency were inconclusive across the studies. Multisite cathodal placements yielded favorable motor response results compared to single-site placement. This review briefly summarized the current mechanistic evidence of the effect of TSS on motor response after SCI. Our findings indicate that optimization of stimulation parameters will require future randomized controlled studies to independently assess the effects of different stimulation parameters under controlled circumstances. [ABSTRACT FROM AUTHOR]

Spinal interneurons which discharge in phase with the respiratory cycle have been repeatedly described over the last 50 years. These spinal respiratory interneurons are part of a complex propriospinal network that is synaptically coupled with respiratory motoneurons. This article summarizes current knowledge regarding spinal respiratory interneurons and emphasizes chemical, electrical and physiological methods for activating spinal respiratory neural circuits. Collectively, the work reviewed here shows that activating spinal interneurons can have a powerful impact on spinal respiratory motor output, and can even drive rhythmic bursting in respiratory motoneuron pools under certain conditions. We propose that the primary functions of spinal respiratory neurons include 1) shaping the respiratory pattern into the final efferent motor output from the spinal respiratory nerves; 2) coordinating respiratory muscle activation across the spinal neuraxis; 3) coordinating postural, locomotor and respiratory movements, and 4) enabling plasticity of respiratory motor output in health and disease. Unlabelled Image • Spinal interneurons (INs) with respiratory discharge patterns are well described. • Spinal respiratory motoneurons are synaptically coupled to spinal INs. • Spinal INs can modulate respiratory motoneuron activity. • Chemical, electrical and physiological methods can activate spinal respiratory INs. • Targeted activation of spinal INs may restore breathing after spinal cord injury. [ABSTRACT FROM AUTHOR]