1. Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers.
- Author
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Jahan I, Fujimoto J, Alam SM, Sato E, Sakaguchi H, and Tamaya T
- Subjects
- Adult, Aged, Disease Progression, Endometrium metabolism, Endometrium pathology, Female, Humans, Immunohistochemistry, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1 biosynthesis, RNA, Messenger metabolism, Endometrial Neoplasms metabolism, Endometrial Neoplasms pathology, Gene Expression Regulation, Neoplastic, Neovascularization, Pathologic, Receptor, PAR-2 biosynthesis
- Abstract
Protease activated receptor-2 (PAR-2) is the second member of a novel family of G-protein coupled seven-transmembrane domain receptors. PAR-2 has been reported to be expressed in various tumors and play a vital role in the regulation of cancer cell growth. The purpose of this study was to clarify the roles of PAR-2 in the angiogenic pathway in uterine endometrial cancers. PAR-2 expression was analyzed in 61 uterine endometrial cancer and 15 normal endometrium tissue specimens. PAR-2 histoscores and mRNA levels were determined by immunohistochemistry and real-time RT-PCR, respectively. Microvessel counts were determined by immunohistochemistry for CD31 and factor VIII-related antigen. The localization of PAR-2 was dominant in the cancer cells of endometrial cancer tissues of all cases studied. PAR-2 histoscores highly correlated with PAR-2 mRNA levels in the same tissues (r=0.87, p<0.001). PAR-2 histoscores and mRNA levels both significantly increased in uterine endometrial cancers with clinical stages (I
- Published
- 2007