Search

Your search keyword '"P, Antinolfi"' showing total 4 results
Start Over Author "P, Antinolfi" Topic neoplasms
4 results on '"P, Antinolfi"'

1. ENOX2 (or tNOX): a new and old molecule with cancer activity involved in tumor prevention and therapy.

Author

Ronconi G, Lessiani G, Spinas E, Kritas SK, Caraffa Al, Saggini A, Antinolfi P, Pizzicannella J, Toniato E, and Conti P

Subjects
Anticarcinogenic Agents pharmacology, Anticarcinogenic Agents therapeutic use, Antineoplastic Agents, Phytogenic pharmacology, Antineoplastic Agents, Phytogenic therapeutic use, Antioxidants pharmacology, Apoptosis drug effects, Biomarkers, Tumor, Capsaicin pharmacology, Capsaicin therapeutic use, Catechin analogs & derivatives, Catechin pharmacology, Catechin therapeutic use, Down-Regulation drug effects, Early Detection of Cancer, Enzyme Induction drug effects, Gene Expression Regulation, Neoplastic drug effects, Humans, Isoflavones pharmacology, Isoflavones therapeutic use, NAD physiology, NADH, NADPH Oxidoreductases antagonists & inhibitors, NADH, NADPH Oxidoreductases blood, Neoplasm Proteins antagonists & inhibitors, Neoplasm Proteins blood, Neoplasm Proteins physiology, Neoplasms enzymology, NADH, NADPH Oxidoreductases physiology, Neoplasms drug therapy, Neoplasms prevention & control
Abstract

Cancer includes a number of related diseases due to abnormal cell proliferation that spreads to nearby tissues. Many compounds (physical, chemical and biological) have been used to try to halt this abnormal proliferation, but the therapeutic results are poor, due also to the side effects. It has been reported that ecto-nicotinamide adenine dinucleotide oxidase di-sulfide-thiol exchanger 2 (ENOX2), also known as tumor-associated nicotinamide adenine dinucleotide oxidase (tNOX), was found to be located on the cancer cell surface, essential for cancer cell growth. Capsaicin and other anti-oxidants are capable of inhibiting tNOX, causing apoptosis of cells, exerting anti-tumor activity. It is interesting that some authors reported that ENOX2 is present in the serum of cancer patients several years before the clinical symptoms of the tumor. However, this result has to be confirmed. In this article we discuss ENOX2 and its inhibition as a hope of improving cancer therapy.

Published
2016

2. Nutrition and cancer prevention.

Author

Tetè S, Nicoletti M, Saggini A, Maccauro G, Rosati M, Conti F, Cianchetti E, Tripodi D, Toniato E, Fulcheri M, Salini V, Caraffa A, Antinolfi P, Frydas S, Pandolfi F, Conti P, Potalivo G, and Theoharides TC

Subjects
Animals, Diet, High-Fat adverse effects, Humans, Neoplasms epidemiology, Neoplasms physiopathology, Risk Assessment, Risk Factors, Diet adverse effects, Neoplasms prevention & control, Nutritional Status, Risk Reduction Behavior
Abstract

Cancer cells invade surrounding tissues and metastasize to distant sites. Diet high in fat is a strong link to, and perhaps causes, a high incidence of tumours. Trans-fatty acid might impair the function and it could be involved in the development of cancer. Cholesterol is also strongly suspected to be involved in the development of tumours, therefore it is important for everyone to eat well, especially for people with cancer to prevent the body tissues from breaking down and helping to rebuild the normal tissue that may have been affected by the treatments. Factors secreted by adipocytes and macrophages such as TNF-alpha and other inflammatory proteins are involved in inflammation in cancer. In addition, MCSF which up-regulates adipocyte tissue is also important for the stimulation of fat cell proliferation and is expressed by human adipocytes. Many cytokines, such as IL-1, IL-6, IL-8, IL-32, IL-33 and MCP-1, are biomarkers for cancer and chronic diseases along with transcription factors NFκB and AP-1; these last two factors are important bioactive substances on the molecular mechanism of the control of genes which in turn affect cellular metabolism. In this paper we revisit the interrelationship between cancer and metabolism.

Published
2012
Full Text
View/download PDF

3. Psychological stress and vitamins.

Author

Conti CM, Fulcheri M, Anogeianaki A, Maccauro G, Teté S, Salini V, Tripodi D, Toniato E, Caraffa A, Antinolfi P, Galzio R, Neri G, Pandolfi F, and Doyle R

Subjects
Avitaminosis immunology, Avitaminosis metabolism, Avitaminosis physiopathology, Humans, Immune Tolerance, Malnutrition metabolism, Malnutrition psychology, Neoplasms immunology, Neoplasms metabolism, Neoplasms physiopathology, Stress, Psychological immunology, Stress, Psychological physiopathology, Stress, Psychological psychology, Vitamins metabolism, Avitaminosis psychology, Neoplasms psychology, Stress, Psychological metabolism
Abstract

Conditions of stress and anxiety have complex interactions with insufficient vitamin intake and malnutrition. This study, based on literature research in Medline, analyzes the inter-relationship between vitamins and stress. This report concerns a number of vitamins that have been receiving much attention in earlier reviews of the literature, for their potential to protect against stress-related events, and focus is placed upon recent findings.

Published
2011

4. ENOX2 (or tNOX): a new and old molecule with cancer activity involved in tumor prevention and therapy

Author

G, Ronconi, G, Lessiani, E, Spinas, S K, Kritas, Al, Caraffa, A, Saggini, P, Antinolfi, J, Pizzicannella, E, Toniato, and P, Conti

Subjects
Down-Regulation, Apoptosis, NAD, Antineoplastic Agents, Phytogenic, Isoflavones, Antioxidants, Catechin, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Enzyme Induction, Neoplasms, Biomarkers, Tumor, Anticarcinogenic Agents, Humans, NADH, NADPH Oxidoreductases, Capsaicin, Early Detection of Cancer
Abstract

Cancer includes a number of related diseases due to abnormal cell proliferation that spreads to nearby tissues. Many compounds (physical, chemical and biological) have been used to try to halt this abnormal proliferation, but the therapeutic results are poor, due also to the side effects. It has been reported that ecto-nicotinamide adenine dinucleotide oxidase di-sulfide-thiol exchanger 2 (ENOX2), also known as tumor-associated nicotinamide adenine dinucleotide oxidase (tNOX), was found to be located on the cancer cell surface, essential for cancer cell growth. Capsaicin and other anti-oxidants are capable of inhibiting tNOX, causing apoptosis of cells, exerting anti-tumor activity. It is interesting that some authors reported that ENOX2 is present in the serum of cancer patients several years before the clinical symptoms of the tumor. However, this result has to be confirmed. In this article we discuss ENOX2 and its inhibition as a hope of improving cancer therapy.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results