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6 results on '"Debusscher L"'

1. Empiric therapy for cancer patients: comparative study of ticarcillin-tobramycin, ticarcillin-cephalothin, and cephalothin-tobramycin.

Author

Klastersky J, Hensgens C, and Debusscher L

Subjects
Bacterial Infections complications, Clinical Trials as Topic, Drug Therapy, Combination, Female, Humans, Kidney drug effects, Male, Neoplasms complications, Anti-Bacterial Agents therapeutic use, Cephalothin therapeutic use, Neoplasms drug therapy, Penicillins therapeutic use, Ticarcillin therapeutic use, Tobramycin therapeutic use
Abstract

Three combinations of antibiotics (cephalothin-tobramycin, cephalothin-ticarcillin, and ticarcillin-tobramycin) were administered empirically to 186 patients with cancer who were suspected of having a life-threatening infection. In approximately one-half of these patients, gram-negative infection was documented bacteriologically and consisted of septicemia in 50% of these patients. The three antimicrobial regimens were similarly effective and resulted in a favorable clinical response in approximately 55% of the patients. The administration of the cephalothin-tobramycin combination was associated with a significantly higher frequency of nephrotoxicity than that of the other two regimens.

Published
1975
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2. Carbenicillin, cefazolin, and amikacin as an empiric therapy for febrile granulocytopenic cancer patients.

Author

Klastersky J, Debusscher L, Weerts-Ruhl D, and Prevost JM

Subjects
Adolescent, Adult, Aged, Agranulocytosis etiology, Amikacin therapeutic use, Anti-Bacterial Agents adverse effects, Carbenicillin therapeutic use, Cefazolin therapeutic use, Drug Therapy, Combination, Female, Fever etiology, Humans, Infections etiology, Male, Middle Aged, Neoplasms complications, Agranulocytosis drug therapy, Anti-Bacterial Agents therapeutic use, Fever drug therapy, Infections drug therapy, Neoplasms drug therapy
Published
1977

5. Bacterial colonization of the respiratory tract in hospitalized patients with malignant diseases.

Author

Debusscher L, Thiry L, and Klastersky J

Subjects
Aged, Drug Resistance, Microbial, Escherichia coli isolation & purification, Female, Humans, Klebsiella isolation & purification, Male, Middle Aged, Pneumonia etiology, Proteus isolation & purification, Pseudomonas isolation & purification, Respiratory Tract Infections diagnosis, Respiratory Tract Infections microbiology, Serologic Tests, Sputum microbiology, Staphylococcal Infections etiology, Staphylococcus isolation & purification, Virus Diseases diagnosis, Gentamicins therapeutic use, Neoplasms complications, Respiratory Tract Infections etiology
Published
1972

6. Fever of unexplained origin in patients with cancer.

Author

Klastersky J, Weerts D, Hensgens C, and Debusscher L

Subjects
Bacterial Infections complications, Carbenicillin therapeutic use, Cephalothin therapeutic use, Endocarditis complications, Endocarditis drug therapy, Ethambutol therapeutic use, Female, Fever of Unknown Origin drug therapy, Gentamicins therapeutic use, Humans, Isoniazid therapeutic use, Leukemia complications, Liver Neoplasms complications, Lymphoma complications, Male, Mycoses complications, Mycoses drug therapy, Neoplasm Metastasis, Virus Diseases complications, Virus Diseases drug therapy, Fever of Unknown Origin complications, Neoplasms complications
Published
1973
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