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3. Species-specific tissue antigens

Author

Bonstein, H. S. and Rose, N. R.

Subjects
Immunodiffusion, Swine, Beta-Globulins, Cross Reactions, Chromatography, DEAE-Cellulose, Absorption, Epitopes, Plasma, Species Specificity, Culture Techniques, Neoplasms, Animals, Ascitic Fluid, Humans, Horses, Antigens, Immunoelectrophoresis, Chromatography, Sheep, Articles, Haplorhini, Hemagglutination Inhibition Tests, Trachea, Liver, Gastric Mucosa, Chromatography, Gel, Cattle, Rabbits
Abstract

Rabbit antisera to human tracheal mucosa, liver and gastric mucosa, after complete absorption with human serum, reacted with extracts of all human tissues tested. Monkey tissue extracts also reacted, but tissues of other species did not. The reactions were attributed to `species-specific tissue antigens'. Two of the most prominent antigens were partially isolated and characterized by chromatography, gel filtration, and electrophoresis. Antigen I migrated as β2-globulin, Antigen E as a β1-globulin. The antigens persisted in malignant and in long-term cultured cells.

Published
1971

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