1. Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study.
- Author
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Okamura M, Kashida Y, Watanabe T, Yasuhara K, Onodera H, Hirose M, Usui T, Tamaoki N, and Mitsumori K
- Subjects
- Administration, Oral, Animals, Carcinogenicity Tests, Carcinogens administration & dosage, Diet, Dose-Response Relationship, Drug, Heterozygote, Male, Mice, Mice, Inbred CBA, Mice, Knockout, Neoplasms, Experimental pathology, Phenolphthalein administration & dosage, Carcinogens toxicity, Genes, p53, Genetic Predisposition to Disease, Neoplasms, Experimental genetics, Phenolphthalein toxicity
- Abstract
Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in female heterozygous p53-knockout TSG mice (C57BL/6 background) at the same dose in a 6-month study. To examine whether carcinogenic potential of phenolphthalein can be detected in other p53-knockout mouse [p53 (+/-)] strains such as p53 (+/-) CBA mice or p53 (+/-) CIEA mice (C57BL/6 background) and their littermates, they were given a diet containing 0, 6000 or 12000 ppm for 6 months. Unequivocal induction of neoplastic lesions was not apparent, suggesting that p53 (+/-) CBA mice and p53 (+/-) CIEA mice are resistant to the induction of malignant lymphomas by the treatment of phenolphthalein.
- Published
- 2003
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