1. Bioactive polymers 68--controlled release of neomycin-furazolidone bicomponent system from xanthan hydrogel.
- Author
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Dumitriu S, Popa MI, Dumitriu M, Dumitriu D, and Tara A
- Subjects
- Delayed-Action Preparations, Drug Carriers, Furazolidone chemical synthesis, Furazolidone chemistry, Furazolidone pharmacology, Gels, Hydrogen-Ion Concentration, Neomycin chemical synthesis, Neomycin chemistry, Neomycin pharmacology, Solutions, Staphylococcus aureus drug effects, Time Factors, Drug Delivery Systems, Furazolidone administration & dosage, Neomycin administration & dosage, Polysaccharides, Bacterial chemistry
- Abstract
The neomycin-furazolidone-xanthan complex has been synthesized. Neomycin is covalently linked to xanthan, while furazolidone is inserted in the hydrogel formed by the reaction between neomycin and xanthan. The content of neomycin and furazolidone depends on the drug rate in the reaction medium. Thus, a zero-order kinetics is obtained for the release of both neomycin and furazolidone in basic medium. The complex's antimicrobial activity is intensified.
- Published
- 1993
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