1. A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas
- Author
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Jessett E, David Feng, Thuyanh V. Nguyen, Yazan N. Billeh, Sophie Lambert, Lindsay Ng, Michael A. Buice, Ramakrishnan Iyer, Chelsea Nayan, Brown D, Sutton B, R.D. Young, Stefan Mihalas, Ali Williford, Brian Hu, Kat North, Julie A. Harris, Greggory Heller, Nicole Hancock, Yang Li, Jérôme Lecoq, John W. Phillips, Emily Gelfand, Séverine Durand, Fuhui Long, Melchior J, Justin T. Kiggins, Kiet Ngo, Nicholas Cain, Sarah A. Naylor, Sam Seid, Karly M. Turner, Hannah Choi, Melissa Reding, John Galbraith, Jackie Swapp, India Kato, Colin Farrell, Johnson K, Joshua H. Siegle, Kara Ronellenfitch, Corbett Bennett, Mollenkopf Ts, Douglas R. Ollerenshaw, Marius Pachitariu, Chvilicek M, David Reid, Kael Dai, Timothy C. Cox, Peter A. Groblewski, Robert Reid, Philip R. Nicovich, Anton Arkhipov, Olsen, Samuel D. Gale, Hytnen R, Luke Esposito, Robert Howard, Jennifer D. Whitesell, Daniel J. Denman, Linzy Casal, Clifford R. Slaughterbeck, Cho A, Shiella Caldejon, Liang E, Xiaoxuan Jia, Tamina K. Ramirez, Wayne Wakeman, Jennifer Luviano, Derric Williams, Daniel Millman, Jung Hoon Lee, Hongkui Zeng, de Vries Sej, Christof Koch, Arielle Leon, Dietzman R, Amy Bernard, Marina Garrett, Carol L. Thompson, Gabriel Koch Ocker, Nile Graddis, Peter Ledochowitsch, Miranda Robertson, Michelle Stoecklin, Jed Perkins, Kyla Mace, Michael Oliver, David Sullivan, and Ruweida Ahmed
- Subjects
Retina ,Visual perception ,medicine.anatomical_structure ,Neocortex ,genetic structures ,Computer science ,Receptive field ,Functional connectivity ,medicine ,Stimulus (physiology) ,Neuroscience - Abstract
The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level functional interactions across multiple levels of this hierarchy is lacking, partially due to the challenge of simultaneously recording activity across numerous regions. Here, we describe a large, open dataset (part of theAllen Brain Observatory) that surveys spiking from units in six cortical and two thalamic regions responding to a battery of visual stimuli. Using spike cross-correlation analysis, we find that inter-area functional connectivity mirrors the anatomical hierarchy from theAllen Mouse Brain Connectivity Atlas. Classical functional measures of hierarchy, including visual response latency, receptive field size, phase-locking to a drifting grating stimulus, and autocorrelation timescale are all correlated with the anatomical hierarchy. Moreover, recordings during a visual task support the behavioral relevance of hierarchical processing. Overall, this dataset and the hierarchy we describe provide a foundation for understanding coding and dynamics in the mouse cortico-thalamic visual system.
- Published
- 2019
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