1. Neisseria meningitidis with decreased susceptibility to penicillin in Istanbul, Turkey.
- Author
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Punar M, Eraksoy H, Cagatay AA, Ozsut H, Kaygusuz A, Calangu S, and Dilmener M
- Subjects
- Adolescent, Adult, Cefotaxime pharmacology, Cephalosporins pharmacology, Cerebrospinal Fluid microbiology, Child, Female, Humans, Male, Microbial Sensitivity Tests methods, Microbial Sensitivity Tests standards, Middle Aged, Nasopharynx microbiology, Turkey, Carrier State microbiology, Meningitis, Meningococcal microbiology, Neisseria meningitidis drug effects, Penicillin Resistance, Penicillins pharmacology
- Abstract
This study was conducted to estimate the rate of decreased susceptibility to penicillin (MIC > 0.06-1 microg/ml) in Neisseria meningitidis isolates in Istanbul, Turkey. A total of 30 isolates collected during a 1-y period from patients with meningitis and from nasopharyngeal carriers were tested for penicillin and cefotaxime susceptibility using the E-test. Two out of 12 (17%) clinical isolates and 11/18 (61%) nasopharyngeal isolates showed decreased susceptibility to penicillin with MICs in the range 0.094-1.0 microg/ml, giving an overall resistance of 43% (n = 13). These data show that continued surveillance of trends in antimicrobial susceptibility of N. meningitidis is important for detecting the emergence of N. meningitidis strains with MICs > 1 microg/ml which may pose serious therapeutic problems.
- Published
- 2002
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