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Your search keyword '"Arthurs, Claire L."' showing total 2 results
Start Over Author "Arthurs, Claire L." Topic natural product
2 results on '"Arthurs, Claire L."'

1. (−)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties

Author

Arthurs, Claire L., Lingley, Katharine F., Piacenti, Michela, Stratford, Ian J., Tatic, Tanja, Whitehead, Roger C., and Wind, Natasha S.

Subjects
*TUMORS, *CELL lines, *CELL culture, *CANCER cells
Abstract

Abstract: Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (−)-quinic acid. The results of bioassays of the target compounds against two lung cancer cell lines, A549 and H460, are presented. [Copyright &y& Elsevier]

Published
2008
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2. Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

Author

Arthurs, Claire L., Wind, Natasha S., Whitehead, Roger C., and Stratford, Ian J.

Subjects
*SHIKIMIC acid, *CARBONYL compounds, *TUMORS, *ANTINEOPLASTIC agents, *BIOLOGICAL assay, *CANCER cells, *CELL lines
Abstract

Abstract: The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. [Copyright &y& Elsevier]

Published
2007
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