1. Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study.
- Author
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Saggini, A., Tripodi, D., Maccauro, G., Castellani, M.L., Anogeianaki, A., Teté, S., Felaco, P., De Luths, M.A., Galzio, R., Fulcheri, M., Theoharides, T.C., Caraffa, A., Antinolfi, P., Felaco, M., Conti, F., Neri, G., Pandolfi, F., Tomato, E., and Shaik-Dasthagirisaheb, Y.B.
- Subjects
TUMOR necrosis factors ,MAST cells ,CONNECTIVE tissues ,NATURAL immunity ,AUTOIMMUNE diseases ,INFLAMMATION - Abstract
Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNFα in their cytoplasmatic granules and release upon activation. TNF-alpha is a potent multifunctional cytokine involved in autoimmune diseases, cancer, allergy, and acute and chronic inflammation. In this study, we revisit the interrelationship between TNFα and mast cells. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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