1. Human leukocyte antigens -A, -B, -C, and -DR and nasopharyngeal carcinoma in northern China.
- Author
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Zhu XN, Chen R, Kong FH, and Liu W
- Subjects
- Adult, Age Factors, China, Gene Frequency, HLA-A Antigens genetics, HLA-A2 Antigen analysis, HLA-B Antigens genetics, HLA-B35 Antigen analysis, HLA-C Antigens genetics, HLA-DR Antigens genetics, HLA-DR2 Antigen analysis, HLA-DR4 Antigen analysis, Humans, Carcinoma immunology, HLA-A Antigens analysis, HLA-B Antigens analysis, HLA-C Antigens analysis, HLA-DR Antigens analysis, Nasopharyngeal Neoplasms immunology
- Abstract
We observed HLA associations in patients with nasopharyngeal carcinoma from northern China. There was an increased risk of nasopharyngeal carcinoma associated with HLA-B35 and a difference in the HLA association between patients with early- and late-onset disease. The frequency of B35 was significantly higher in patients than in control subjects, especially in early-onset patients (less than 30 years old). Late-onset patients had a higher frequency of DR2 as compared with normal subjects.
- Published
- 1990
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