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Start Over Author "PETRY, M. E." Topic naphthalenes

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1. Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.

Author

Krapcho AP, Petry ME, and Hacker MP

Subjects
Animals, Antineoplastic Agents therapeutic use, Chemical Phenomena, Chemistry, Leukemia L1210 drug therapy, Mice, Naphthalenes therapeutic use, Structure-Activity Relationship, Thiophenes therapeutic use, Antineoplastic Agents chemical synthesis, Naphthalenes chemical synthesis, Thiophenes chemical synthesis
Abstract

A number of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4, 9-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone.

Published
1990
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